Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous neurological disorders characterized by pathophysiologic hallmark of length-dependent distal axonal degeneration of the corticospinal tracts. The prominent features of this pathological condition are progressive spasticity and weakness of the lower limbs. To date, 72 spastic gait disease-loci and 55 spastic paraplegia genes (SPGs) have been identified. All modes of inheritance (autosomal dominant, autosomal recessive, and X-linked) have been described. Recently, a late onset spastic gait disorder with maternal trait of inheritance has been reported, as well as mutations in genes not yet classified as spastic gait disease. Several cellular processes are involved in its pathogenesis, such as membrane and axonal transport, endoplasmic reticulum membrane modeling and shaping, mitochondrial function, DNA repair, autophagy, and abnormalities in lipid metabolism and myelination processes. Moreover, recent evidences have been found about the impairment of endosome membrane trafficking in vesicle formation and about the involvement of oxidative stress and mtDNA polymorphisms in the onset of the disease. Interactome networks have been postulated by bioinformatics and biological analyses of spastic paraplegia genes, which would contribute to the development of new therapeutic approaches.

Lo Giudice, T., Lombardi, F., Santorelli, F., Kawarai, T., Orlacchio, A. (2014). Hereditary spastic paraplegia: Clinical-genetic characteristics and evolving molecular mechanisms. EXPERIMENTAL NEUROLOGY, 261C, 518-539 [10.1016/j.expneurol.2014.06.011].

Hereditary spastic paraplegia: Clinical-genetic characteristics and evolving molecular mechanisms

ORLACCHIO, ANTONIO
2014-11-01

Abstract

Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous neurological disorders characterized by pathophysiologic hallmark of length-dependent distal axonal degeneration of the corticospinal tracts. The prominent features of this pathological condition are progressive spasticity and weakness of the lower limbs. To date, 72 spastic gait disease-loci and 55 spastic paraplegia genes (SPGs) have been identified. All modes of inheritance (autosomal dominant, autosomal recessive, and X-linked) have been described. Recently, a late onset spastic gait disorder with maternal trait of inheritance has been reported, as well as mutations in genes not yet classified as spastic gait disease. Several cellular processes are involved in its pathogenesis, such as membrane and axonal transport, endoplasmic reticulum membrane modeling and shaping, mitochondrial function, DNA repair, autophagy, and abnormalities in lipid metabolism and myelination processes. Moreover, recent evidences have been found about the impairment of endosome membrane trafficking in vesicle formation and about the involvement of oxidative stress and mtDNA polymorphisms in the onset of the disease. Interactome networks have been postulated by bioinformatics and biological analyses of spastic paraplegia genes, which would contribute to the development of new therapeutic approaches.
nov-2014
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - NEUROLOGIA
English
Con Impact Factor ISI
Phenotype; Hereditary spastic paraplegia; Molecular genetics; Neurodegenerative mechanisms; Neurology
Lo Giudice, T., Lombardi, F., Santorelli, F., Kawarai, T., Orlacchio, A. (2014). Hereditary spastic paraplegia: Clinical-genetic characteristics and evolving molecular mechanisms. EXPERIMENTAL NEUROLOGY, 261C, 518-539 [10.1016/j.expneurol.2014.06.011].
Lo Giudice, T; Lombardi, F; Santorelli, F; Kawarai, T; Orlacchio, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/99287
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