Neuronal nitric oxide synthase (nNOS) and peroxisome proliferator activated receptor γ co-activator 1α (PGC-1α) are two fundamental factors involved in the regulation of skeletal muscle cell metabolism. nNOS exists as several alternatively spliced variants, each having a specific pattern of subcellular localisation. Nitric oxide (NO) functions as a second messenger in signal transduction pathways that lead to the expression of metabolic genes involved in oxidative metabolism, vasodilatation and skeletal muscle contraction. PGC-1α is a transcriptional coactivator and represents a master regulator of mitochondrial biogenesis by promoting the transcription of mitochondrial genes. PGC-1α can be induced during physical exercise, and it plays a key role in coordinating the oxidation of intracellular fatty acids with mitochondrial remodelling. Several lines of evidence demonstrate that NO could act as a key regulator of PGC-1α expression; however, the link between nNOS and PGC-1α in skeletal muscle remains only poorly understood. In this Commentary, we review important metabolic pathways that are governed by nNOS and PGC-1α, and aim to highlight how they might intersect and cooperatively regulate skeletal muscle mitochondrial and lipid energetic metabolism and contraction.

Baldelli, S., LETTIERI BARBATO, D., Tatulli, G., Aquilano, K., Ciriolo, M.r. (2014). The role of nNOS and PGC-1α in skeletal muscle cells. JOURNAL OF CELL SCIENCE, 127(22), 4813-4820 [10.1242/jcs.154229].

The role of nNOS and PGC-1α in skeletal muscle cells

LETTIERI BARBATO, DANIELE;AQUILANO, KATIA;CIRIOLO, MARIA ROSA
2014-11-15

Abstract

Neuronal nitric oxide synthase (nNOS) and peroxisome proliferator activated receptor γ co-activator 1α (PGC-1α) are two fundamental factors involved in the regulation of skeletal muscle cell metabolism. nNOS exists as several alternatively spliced variants, each having a specific pattern of subcellular localisation. Nitric oxide (NO) functions as a second messenger in signal transduction pathways that lead to the expression of metabolic genes involved in oxidative metabolism, vasodilatation and skeletal muscle contraction. PGC-1α is a transcriptional coactivator and represents a master regulator of mitochondrial biogenesis by promoting the transcription of mitochondrial genes. PGC-1α can be induced during physical exercise, and it plays a key role in coordinating the oxidation of intracellular fatty acids with mitochondrial remodelling. Several lines of evidence demonstrate that NO could act as a key regulator of PGC-1α expression; however, the link between nNOS and PGC-1α in skeletal muscle remains only poorly understood. In this Commentary, we review important metabolic pathways that are governed by nNOS and PGC-1α, and aim to highlight how they might intersect and cooperatively regulate skeletal muscle mitochondrial and lipid energetic metabolism and contraction.
15-nov-2014
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/10 - BIOCHIMICA
Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE
English
Mitochondrial metabolism; Nitric oxide; Mitochondrial biogenesis; Lipid metabolism
Baldelli, S., LETTIERI BARBATO, D., Tatulli, G., Aquilano, K., Ciriolo, M.r. (2014). The role of nNOS and PGC-1α in skeletal muscle cells. JOURNAL OF CELL SCIENCE, 127(22), 4813-4820 [10.1242/jcs.154229].
Baldelli, S; LETTIERI BARBATO, D; Tatulli, G; Aquilano, K; Ciriolo, Mr
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/99156
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