Neoplasia cells exfoliated from colorectal epithelium have dysfunctional apoptotic mechanisms, thus it is possible to identify high-molecular weight DNA fragments in feces. This prospective single-center study was performed to evaluate the sensitivity and specificity of fecal-based DNA integrity versus immunological fecal occult blood test (iFOBT) and calprotectin for colorectal cancer (CRC) and adenoma detection.
Kalimutho, M., DEL VECCHIO BLANCO, G., Cretella, M., Mannisi, E., Sileri, P., Formosa, A., et al. (2011). A simplified, non-invasive fecal-based DNA integrity assay and iFOBT for colorectal cancer detection. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 26(5), 583-592 [10.1007/s00384-010-1128-x].
A simplified, non-invasive fecal-based DNA integrity assay and iFOBT for colorectal cancer detection
DEL VECCHIO BLANCO, GIOVANNA;SILERI, PIERPAOLO;PALLONE, FRANCESCO;FEDERICI, GIORGIO;BERNARDINI, SERGIO
2011-05-01
Abstract
Neoplasia cells exfoliated from colorectal epithelium have dysfunctional apoptotic mechanisms, thus it is possible to identify high-molecular weight DNA fragments in feces. This prospective single-center study was performed to evaluate the sensitivity and specificity of fecal-based DNA integrity versus immunological fecal occult blood test (iFOBT) and calprotectin for colorectal cancer (CRC) and adenoma detection.| File | Dimensione | Formato | |
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