The cerebrospinal fluid (CSF) biomarkers amyloid β (Aβ)-42, total-tau (T-tau), and phosphorylated-tau (P-tau) demonstrate good diagnostic accuracy for Alzheimer's disease (AD). However, there are large variations in biomarker measurements between studies, and between and within laboratories. The Alzheimer's Association has initiated a global quality control program to estimate and monitor variability of measurements, quantify batch-to-batch assay variations, and identify sources of variability. In this article, we present the results from the first two rounds of the program.
Mattsson, N., Andreasson, U., Persson, S., Arai, H., Batish, S., Bernardini, S., et al. (2011). The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. ALZHEIMER'S & DEMENTIA, 7(4), 386-395.e6 [10.1016/j.jalz.2011.05.2243].
The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers
BERNARDINI, SERGIO;STEFANI, ALESSANDRO;
2011-07-01
Abstract
The cerebrospinal fluid (CSF) biomarkers amyloid β (Aβ)-42, total-tau (T-tau), and phosphorylated-tau (P-tau) demonstrate good diagnostic accuracy for Alzheimer's disease (AD). However, there are large variations in biomarker measurements between studies, and between and within laboratories. The Alzheimer's Association has initiated a global quality control program to estimate and monitor variability of measurements, quantify batch-to-batch assay variations, and identify sources of variability. In this article, we present the results from the first two rounds of the program.| File | Dimensione | Formato | |
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