MicroRNAs are tiny non-coding small endogenous RNAs that regulate gene expression by translational repression, mRNA cleavage and mRNA inhibition. The aim of this study was to investigate the hypermethylation of miR-34b/c and miR-148a in colorectal cancer, and correlate this data to clinicopathological features. We also aimed to evaluate the hypermethylation of miR-34b/c in faeces specimens as a novel non-invasive faecal-DNA-based screening marker.
Kalimutho, M., Di Cecilia, S., DEL VECCHIO BLANCO, G., Roviello, F., Sileri, P., Cretella, M., et al. (2011). Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer. BRITISH JOURNAL OF CANCER, 104(11), 1770-1778 [10.1038/bjc.2011.82].
Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer
DEL VECCHIO BLANCO, GIOVANNA;SILERI, PIERPAOLO;PALLONE, FRANCESCO;FEDERICI, GIORGIO;BERNARDINI, SERGIO
2011-05-24
Abstract
MicroRNAs are tiny non-coding small endogenous RNAs that regulate gene expression by translational repression, mRNA cleavage and mRNA inhibition. The aim of this study was to investigate the hypermethylation of miR-34b/c and miR-148a in colorectal cancer, and correlate this data to clinicopathological features. We also aimed to evaluate the hypermethylation of miR-34b/c in faeces specimens as a novel non-invasive faecal-DNA-based screening marker.| File | Dimensione | Formato | |
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