A new class of compounds able to block the replication of subgenomic HCV RNA in liver cells is described. 3-Amino-2(5H)furanones 4 may be regarded as diketoacid analogues and were obtained by basic rearrangement of the isoxazolidine nucleus.
Iannazzo, D., Piperno, A., Romeo, G., Romeo, R., Rescifina, A., Balestrieri, E., et al. (2008). 3-Amino-2(5H)furanones as inhibitors of subgenomic hepatitis C virus RNA replication. BIOORGANIC & MEDICINAL CHEMISTRY, 16, 9610-9615.
3-Amino-2(5H)furanones as inhibitors of subgenomic hepatitis C virus RNA replication
BALESTRIERI, EMANUELA;MACCHI, BEATRICE;
2008-01-01
Abstract
A new class of compounds able to block the replication of subgenomic HCV RNA in liver cells is described. 3-Amino-2(5H)furanones 4 may be regarded as diketoacid analogues and were obtained by basic rearrangement of the isoxazolidine nucleus.File in questo prodotto:
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