A new class of compounds able to block the replication of subgenomic HCV RNA in liver cells is described. 3-Amino-2(5H)furanones 4 may be regarded as diketoacid analogues and were obtained by basic rearrangement of the isoxazolidine nucleus.

Iannazzo, D., Piperno, A., Romeo, G., Romeo, R., Rescifina, A., Balestrieri, E., et al. (2008). 3-Amino-2(5H)furanones as inhibitors of subgenomic hepatitis C virus RNA replication. BIOORGANIC & MEDICINAL CHEMISTRY, 16, 9610-9615.

3-Amino-2(5H)furanones as inhibitors of subgenomic hepatitis C virus RNA replication

BALESTRIERI, EMANUELA;MACCHI, BEATRICE;
2008-01-01

Abstract

A new class of compounds able to block the replication of subgenomic HCV RNA in liver cells is described. 3-Amino-2(5H)furanones 4 may be regarded as diketoacid analogues and were obtained by basic rearrangement of the isoxazolidine nucleus.
2008
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/14 - FARMACOLOGIA
Settore CHIM/06 - CHIMICA ORGANICA
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Con Impact Factor ISI
DKA HCV Furanones 1,3-Dipolar cycloaddition Isoxazolidines
Iannazzo, D., Piperno, A., Romeo, G., Romeo, R., Rescifina, A., Balestrieri, E., et al. (2008). 3-Amino-2(5H)furanones as inhibitors of subgenomic hepatitis C virus RNA replication. BIOORGANIC & MEDICINAL CHEMISTRY, 16, 9610-9615.
Iannazzo, D; Piperno, A; Romeo, G; Romeo, R; Rescifina, A; Balestrieri, E; Macchi, B; Mastino, A; Cortese, R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/9727
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