The physiological roles played by the tripeptide glutathione have greatly advanced over the past decades superimposing the research on free radicals, oxidative stress and, more recently, redox signaling. In particular, GSH is involved in nutrient metabolism, antioxidant defense, and regulation of cellular metabolic functions ranging from gene expression, DNA and protein synthesis to signal transduction, cell proliferation and apoptosis. This review will be focused on the role of GSH in cell signaling by analysing the more recent advancements about its capability to modulate nitroxidative stress, autophagy, and viral infection.

Aquilano, K., Baldelli, S., Ciriolo, M.r. (2014). Glutathione: new roles in redox signaling for an old antioxidant. FRONTIERS IN PHARMACOLOGY, 5, 196-196 [10.3389/fphar.2014.00196].

Glutathione: new roles in redox signaling for an old antioxidant

AQUILANO, KATIA;CIRIOLO, MARIA ROSA
2014-01-01

Abstract

The physiological roles played by the tripeptide glutathione have greatly advanced over the past decades superimposing the research on free radicals, oxidative stress and, more recently, redox signaling. In particular, GSH is involved in nutrient metabolism, antioxidant defense, and regulation of cellular metabolic functions ranging from gene expression, DNA and protein synthesis to signal transduction, cell proliferation and apoptosis. This review will be focused on the role of GSH in cell signaling by analysing the more recent advancements about its capability to modulate nitroxidative stress, autophagy, and viral infection.
2014
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/10 - BIOCHIMICA
Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE
English
Con Impact Factor ISI
Aquilano, K., Baldelli, S., Ciriolo, M.r. (2014). Glutathione: new roles in redox signaling for an old antioxidant. FRONTIERS IN PHARMACOLOGY, 5, 196-196 [10.3389/fphar.2014.00196].
Aquilano, K; Baldelli, S; Ciriolo, Mr
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/97247
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