Therapeutic antibodies against tumor necrosis factor α (anti-TNF) are effective in patients with Crohn's disease (CD). Mucosal healing is a surrogate marker of efficacy, but little is known about the effects of anti-TNF agents on structural damage in the intestine. Small-intestine contrast ultrasonography (SICUS) is a valuable tool for assessing CD lesions. A new sonographic quantitative index (the sonographic lesion index for CD [SLIC]) was developed to quantify changes in CD lesions detected by SICUS. We explored whether the SLIC can be used to monitor transmural bowel damage in CD patients during anti-TNF therapy.

Zorzi, F., Stasi, E., Bevivino, G., Scarozza, P., Biancone, L., Zuzzi, S., et al. (2014). A Sonographic Lesion Index for Crohn's Disease Helps Monitor Changes in Transmural Bowel Damage During Therapy. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 12(12), 2071-2077 [10.1016/j.cgh.2014.04.036].

A Sonographic Lesion Index for Crohn's Disease Helps Monitor Changes in Transmural Bowel Damage During Therapy

STASI, ELISA;BIANCONE, LIVIA;ZUZZI, SARA;ROSSI, CARLA;PALLONE, FRANCESCO;CALABRESE, EMMA
2014-05-06

Abstract

Therapeutic antibodies against tumor necrosis factor α (anti-TNF) are effective in patients with Crohn's disease (CD). Mucosal healing is a surrogate marker of efficacy, but little is known about the effects of anti-TNF agents on structural damage in the intestine. Small-intestine contrast ultrasonography (SICUS) is a valuable tool for assessing CD lesions. A new sonographic quantitative index (the sonographic lesion index for CD [SLIC]) was developed to quantify changes in CD lesions detected by SICUS. We explored whether the SLIC can be used to monitor transmural bowel damage in CD patients during anti-TNF therapy.
6-mag-2014
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/12 - GASTROENTEROLOGIA
English
Crohn's Disease; Anti-TNFα; Transmural Bowel Damage; SICUS; Drug Monitoring
Zorzi, F., Stasi, E., Bevivino, G., Scarozza, P., Biancone, L., Zuzzi, S., et al. (2014). A Sonographic Lesion Index for Crohn's Disease Helps Monitor Changes in Transmural Bowel Damage During Therapy. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 12(12), 2071-2077 [10.1016/j.cgh.2014.04.036].
Zorzi, F; Stasi, E; Bevivino, G; Scarozza, P; Biancone, L; Zuzzi, S; Rossi, C; Pallone, F; Calabrese, E
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/97037
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