We have compared the long-term effects of different corticosteroids on glucose metabolism by carring out a 75 g oral glucose tolerance test in 27 subjects before and after the administration of deflazacort or betamethasone for two months in random balanced sequence. Fasting plasma glucose and insulin concentrations were significantly higher after betamethasone, whereas deflazacort increased only fasting plasma insulin. After oral glucose there were significant increases in blood glucose and insulin after betamethasone compared with deflazacort. These results suggest that the degree of glucose intolerance and insulin resistance depends on the steroid used and on the dose given, although long-term treatment with deflazacort has a smaller effect on glucose metabolism than betamethasone.

Bruno, A., Pagano, G., Benzi, L., Di Ciani, G., Spallone, V., Calabrese, G., et al. (1992). Change in glucose metabolism after long-term treatment with deflazacort and betamethasone. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 43(1), 47-50.

Change in glucose metabolism after long-term treatment with deflazacort and betamethasone

SPALLONE, VINCENZA;
1992-01-01

Abstract

We have compared the long-term effects of different corticosteroids on glucose metabolism by carring out a 75 g oral glucose tolerance test in 27 subjects before and after the administration of deflazacort or betamethasone for two months in random balanced sequence. Fasting plasma glucose and insulin concentrations were significantly higher after betamethasone, whereas deflazacort increased only fasting plasma insulin. After oral glucose there were significant increases in blood glucose and insulin after betamethasone compared with deflazacort. These results suggest that the degree of glucose intolerance and insulin resistance depends on the steroid used and on the dose given, although long-term treatment with deflazacort has a smaller effect on glucose metabolism than betamethasone.
1992
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/13 - ENDOCRINOLOGIA
English
Con Impact Factor ISI
betamethasone; deflazacort; Glucocorticoids; Glucose metabolism; insulin resistance
Bruno, A., Pagano, G., Benzi, L., Di Ciani, G., Spallone, V., Calabrese, G., et al. (1992). Change in glucose metabolism after long-term treatment with deflazacort and betamethasone. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 43(1), 47-50.
Bruno, A; Pagano, G; Benzi, L; Di Ciani, G; Spallone, V; Calabrese, G; Passeri, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/95210
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