Purpose: To investigate the intraocular pressure (IOP) reduction with prostaglandin analogs (PGAs)-timolol fixed combinations versus the unfixed combination of the same PGAs and timolol 0.1% in gel-forming carbomer. Methods: Patients with primary open-angle glaucoma (POAG) receiving for at least 4 weeks the fixed combinations of PGA-timolol, administered once a day in the evening (0.005% latanoprost with 0.5% timolol, 0.004% travoprost with 0.5% timolol, 0.03% bimatoprost with 0.5% timolol) were switched to an unfixed combination of the same PGA (once a day in the evening) with timolol 0.1% in gel-forming carbomer (once a day in the morning) for at least 4 weeks. The primary endpoint was to compare efficacy of fixed vs unfixed combinations in lowering IOP. The effects of both regimens on short-term IOP fluctuations were also assessed. Results: A total of 32 patients (64 eyes) fulfilled inclusion criteria: 17 patients received latanoprost-timolol fixed combination, 9 travoprost-timolol fixed combination, 6 bimatoprost-timolol fixed combination. For all considered time periods each unfixed combination induced an IOP reduction significantly higher than the corresponding fixed combination (paired t test: p<0.05 in all measurements). The diurnal IOP reduction was significantly higher during the unfixed combinations (p<0.001). Unfixed combinations significantly decreased IOP diurnal fluctuations and increased the percentage of patients with daily IOP fluctuation ≤2 mm Hg. Conclusion: In this pilot study, PGA and timolol seems to be more effective in POAG treatment when administered as unfixed combinations, reducing both IOP and daily fluctuations. The once a day timolol 0.1% gel-forming carbomer may be a valuable option in PGA-timolol unfixed combination regimen.
Nucci, C., Varesi, C., Martucci, A., Cesareo, M., Cedrone, C., Mancino, R., et al. (2013). Efficacy of timolol 0.1% gel and a prostaglandin analog in an unfixed combination compared to the corresponding fixed combinations. EUROPEAN JOURNAL OF OPHTHALMOLOGY, 23(5), 683-689.
|Tipologia:||Articolo su rivista|
|Citazione:||Nucci, C., Varesi, C., Martucci, A., Cesareo, M., Cedrone, C., Mancino, R., et al. (2013). Efficacy of timolol 0.1% gel and a prostaglandin analog in an unfixed combination compared to the corresponding fixed combinations. EUROPEAN JOURNAL OF OPHTHALMOLOGY, 23(5), 683-689.|
|Settore Scientifico Disciplinare:||Settore MED/30 - Malattie Apparato Visivo|
|Revisione (peer review):||Esperti anonimi|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.5301/ejo.5000292|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||15-apr-2013|
|Titolo:||Efficacy of timolol 0.1% gel and a prostaglandin analog in an unfixed combination compared to the corresponding fixed combinations|
|Autori:||Nucci, C; Varesi, C; Martucci, A; Cesareo, M; Cedrone, C; Mancino, R; Cerulli, L|
|Appare nelle tipologie:||01 - Articolo su rivista|