Biodistribution and pharmacokinetics of polymer shelled microbubbles (MBs), embedded with superparamagnetic iron oxide nanoparticles (SPION) in the shell, were determined in rats using dynamic Magnetic Resonance (MR) imaging. The histological survey of tissue samples showed that SPION MBs were taken up by macrophages in the lungs, spleen and liver. The elimination half-life of SPION MBs was longer than that of SPION. This study shows that MRI is a reliable and non-invasive method for pharmacokinetic calculations.

Barrefelt, A., Paradossi, G., Asem, H., Margheritelli, S., Saghafian, M., Oddo, L., et al. (2014). Dynamic MR Imaging, Biodistribution and Pharmacokinetics of Polymer Shelled Microbubbles Containing Spion. NANO, 9(6), 1450069 [10.1142/S1793292014500696].

Dynamic MR Imaging, Biodistribution and Pharmacokinetics of Polymer Shelled Microbubbles Containing Spion

PARADOSSI, GAIO;ODDO, LETIZIA;
2014

Abstract

Biodistribution and pharmacokinetics of polymer shelled microbubbles (MBs), embedded with superparamagnetic iron oxide nanoparticles (SPION) in the shell, were determined in rats using dynamic Magnetic Resonance (MR) imaging. The histological survey of tissue samples showed that SPION MBs were taken up by macrophages in the lungs, spleen and liver. The elimination half-life of SPION MBs was longer than that of SPION. This study shows that MRI is a reliable and non-invasive method for pharmacokinetic calculations.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore CHIM/02 - Chimica Fisica
English
Con Impact Factor ISI
Barrefelt, A., Paradossi, G., Asem, H., Margheritelli, S., Saghafian, M., Oddo, L., et al. (2014). Dynamic MR Imaging, Biodistribution and Pharmacokinetics of Polymer Shelled Microbubbles Containing Spion. NANO, 9(6), 1450069 [10.1142/S1793292014500696].
Barrefelt, A; Paradossi, G; Asem, H; Margheritelli, S; Saghafian, M; Oddo, L; Muhammed, M; Aspelin, P; Hassan, M; Brismar, Tb
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/94950
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