Combinations of microbubbles (MBs) and superparamagnetic iron oxide nanoparticles (SPIONs) are used to fabricate dual contrast agents for ultrasound and MRI. This study examines the viscoelastic and oscillation characteristics of two MB types that are manufactured with SPIONs and either anchored chemically on the surface (MBs-chem) or physically embedded (MBs-phys) into a polymer shell. A linearized Church model was employed to simultaneously fit attenuation coefficients and phase velocity spectra that were acquired experimentally. The model predicted lower viscoelastic modulus values, undamped resonance frequencies and total damping ratios for MBs-chem. MBs-chem had a resonance frequency of approximately 13 MHz and a damping ratio of approximately 0.9; thus, MBs-chem can potentially be used as a conventional ultrasound contrast agent with the combined functionality of MRI detection. In contrast, MBs-phys had a resonance frequency and damping of 28 MHz and 1.2, respectively, and requires further modification of clinically available contrast pulse sequences to be visualized.

Kothapalli, S.V., Oddo, L., Paradossi, G., Brodin, L.A., & Grishnekov, D. (2014). Assessment of the Viscoelastic and Oscillation Properties of a Nano-Engineered Multimodality Contrast Agent. ULTRASOUND IN MEDICINE AND BIOLOGY, 40(10), 2476-2487 [10.1016/j.ultrasmedbio.2014.05.018].

Assessment of the Viscoelastic and Oscillation Properties of a Nano-Engineered Multimodality Contrast Agent

ODDO, LETIZIA;PARADOSSI, GAIO;
2014

Abstract

Combinations of microbubbles (MBs) and superparamagnetic iron oxide nanoparticles (SPIONs) are used to fabricate dual contrast agents for ultrasound and MRI. This study examines the viscoelastic and oscillation characteristics of two MB types that are manufactured with SPIONs and either anchored chemically on the surface (MBs-chem) or physically embedded (MBs-phys) into a polymer shell. A linearized Church model was employed to simultaneously fit attenuation coefficients and phase velocity spectra that were acquired experimentally. The model predicted lower viscoelastic modulus values, undamped resonance frequencies and total damping ratios for MBs-chem. MBs-chem had a resonance frequency of approximately 13 MHz and a damping ratio of approximately 0.9; thus, MBs-chem can potentially be used as a conventional ultrasound contrast agent with the combined functionality of MRI detection. In contrast, MBs-phys had a resonance frequency and damping of 28 MHz and 1.2, respectively, and requires further modification of clinically available contrast pulse sequences to be visualized.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore CHIM/02 - Chimica Fisica
English
Con Impact Factor ISI
Ultrasound contrast agent, Magnetic microbubbles, Fe3O4 nanoparticles, Harmonic oscillation, Viscoelastic properties
Kothapalli, S.V., Oddo, L., Paradossi, G., Brodin, L.A., & Grishnekov, D. (2014). Assessment of the Viscoelastic and Oscillation Properties of a Nano-Engineered Multimodality Contrast Agent. ULTRASOUND IN MEDICINE AND BIOLOGY, 40(10), 2476-2487 [10.1016/j.ultrasmedbio.2014.05.018].
Kothapalli, S; Oddo, L; Paradossi, G; Brodin, L; Grishnekov, D
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/94898
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 8
social impact