Background and Aim. p53 activity plays a role in muscle homeostasis and skeletal muscle differentiation; all pathways that lead to sarcopenia are related to p53 activities. We investigate the allelic frequency of the TP53 codon 72 in exon 4 polymorphism in the Italian female population and the association with appendicular skeletal muscle mass index in normal weight (NW), normal weight obese (NWO), and preobese-obese (Preob-Ob) subjects. Methods. We evaluated anthropometry, body composition, and p53 polymorphism in 140 women distinguished in NW, NWO, and Preob-Ob. Results. ∗Arg/∗Arg genotype increases sarcopenia risk up to 20% (∗Arg/∗Arg genotype OR = 1.20; 95% CI = 0.48–2.9; ∗proallele carriers OR = 0.83; 95% CI = 0.83–2.06). The risk of being sarcopenic for ∗Arg/∗Arg genotype in NWO and Preob-Ob is 31% higher than NW carriers of ∗proallele (RR = 0,31, 95% CI = 0,15–0,66, P = 0,0079). We developed a model able to predict sarcopenia risk based on age, body fat, and p53 polymorphism. Conclusion. Our study evidences that genotyping TP53 polymorphism could be a useful new genetic approach, in association with body composition evaluations, to assess sarcopenia risk.

DI RENZO, L., Gratteri, S., Sarlo, F., Cabibbo, A., Colica, C., DE LORENZO, A. (2014). Individually Tailored Screening of Susceptibility to Sarcopenia Using p53 Codon 72 Polymorphism, Phenotypes, and Conventional Risk Factors. DISEASE MARKERS, 2014, 743634 [10.1155/2014/743634].

Individually Tailored Screening of Susceptibility to Sarcopenia Using p53 Codon 72 Polymorphism, Phenotypes, and Conventional Risk Factors

DI RENZO, LAURA;CABIBBO, ANDREA;DE LORENZO, ANTONINO
2014-01-01

Abstract

Background and Aim. p53 activity plays a role in muscle homeostasis and skeletal muscle differentiation; all pathways that lead to sarcopenia are related to p53 activities. We investigate the allelic frequency of the TP53 codon 72 in exon 4 polymorphism in the Italian female population and the association with appendicular skeletal muscle mass index in normal weight (NW), normal weight obese (NWO), and preobese-obese (Preob-Ob) subjects. Methods. We evaluated anthropometry, body composition, and p53 polymorphism in 140 women distinguished in NW, NWO, and Preob-Ob. Results. ∗Arg/∗Arg genotype increases sarcopenia risk up to 20% (∗Arg/∗Arg genotype OR = 1.20; 95% CI = 0.48–2.9; ∗proallele carriers OR = 0.83; 95% CI = 0.83–2.06). The risk of being sarcopenic for ∗Arg/∗Arg genotype in NWO and Preob-Ob is 31% higher than NW carriers of ∗proallele (RR = 0,31, 95% CI = 0,15–0,66, P = 0,0079). We developed a model able to predict sarcopenia risk based on age, body fat, and p53 polymorphism. Conclusion. Our study evidences that genotyping TP53 polymorphism could be a useful new genetic approach, in association with body composition evaluations, to assess sarcopenia risk.
2014
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE
English
Con Impact Factor ISI
Sarcopenia;nutrition;p53;genetics;polymorphism
http://www.hindawi.com/journals/dm/2014/743634/
DI RENZO, L., Gratteri, S., Sarlo, F., Cabibbo, A., Colica, C., DE LORENZO, A. (2014). Individually Tailored Screening of Susceptibility to Sarcopenia Using p53 Codon 72 Polymorphism, Phenotypes, and Conventional Risk Factors. DISEASE MARKERS, 2014, 743634 [10.1155/2014/743634].
DI RENZO, L; Gratteri, S; Sarlo, F; Cabibbo, A; Colica, C; DE LORENZO, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/94847
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