Autophagy inhibits survival of intracellular Mycobacterium tuberculosis when induced by rapamycin or interferon γ (IFN-γ), but it remains unclear whether M. tuberculosis itself can induce autophagy and whether T cells play a role in M. tuberculosis-mediated autophagy. The aim of this study was to evaluate the impact of M. tuberculosis on autophagy in human primary macrophages and the role of specific T cells in this process.

Petruccioli, E., Romagnoli, A., Corazzari, M., Coccia, E., Butera, O., Delogu, G., et al. (2012). Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages. THE JOURNAL OF INFECTIOUS DISEASES, 205(9), 1425-1435 [10.1093/infdis/jis226].

Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages

CORAZZARI, MARCO;PIACENTINI, MAURO;
2012-05-01

Abstract

Autophagy inhibits survival of intracellular Mycobacterium tuberculosis when induced by rapamycin or interferon γ (IFN-γ), but it remains unclear whether M. tuberculosis itself can induce autophagy and whether T cells play a role in M. tuberculosis-mediated autophagy. The aim of this study was to evaluate the impact of M. tuberculosis on autophagy in human primary macrophages and the role of specific T cells in this process.
1-mag-2012
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/06 - ANATOMIA COMPARATA E CITOLOGIA
English
Con Impact Factor ISI
Macrophages; Microscopy, Confocal; Real-Time Polymerase Chain Reaction; Tumor Necrosis Factor-alpha; Interferon-gamma; Autophagy; Humans; Phagosomes; Blotting, Western; RNA-Binding Proteins; Cell Communication; Tuberculosis; Stem Cells; Mycobacterium tuberculosis; T-Lymphocytes
Petruccioli, E., Romagnoli, A., Corazzari, M., Coccia, E., Butera, O., Delogu, G., et al. (2012). Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages. THE JOURNAL OF INFECTIOUS DISEASES, 205(9), 1425-1435 [10.1093/infdis/jis226].
Petruccioli, E; Romagnoli, A; Corazzari, M; Coccia, E; Butera, O; Delogu, G; Piacentini, M; Girardi, E; Fimia, G; Goletti, D
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/93968
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