Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as 'accidental cell death' (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, correlating with the fact that its course can be altered by pharmacologic or genetic interventions. 'Regulated cell death' (RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail. The biochemical phenomena that accompany RCD may be harnessed to classify it into a few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of executioner caspases in the course of apoptosis, does not exert true cytoprotective effects in the mammalian system, but simply alters the kinetics of cellular demise as it shifts its morphologic and biochemical correlates. Conversely, bona fide cytoprotection can be achieved by inhibiting the transduction of lethal signals in the early phases of the process, when adaptive responses are still operational. Thus, the mechanisms that truly execute RCD may be less understood, less inhibitable and perhaps more homogeneous than previously thought. Here, the Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death.

Galluzzi, L., Bravo San Pedro, J., Vitale, A., Aaronson, S., Abrams, J., Adam, D., et al. (2015). Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. CELL DEATH AND DIFFERENTIATION, 22(1), 58-73 [10.1038/cdd.2014.137].

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

Campanella, M;CANDI, ELEONORA;CECCONI, FRANCESCO;DE LAURENZI, VINCENZO;MELINO, SONIA MICHAELA;PIACENTINI, MAURO;MELINO, GENNARO;
2015-01-01

Abstract

Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as 'accidental cell death' (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, correlating with the fact that its course can be altered by pharmacologic or genetic interventions. 'Regulated cell death' (RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail. The biochemical phenomena that accompany RCD may be harnessed to classify it into a few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of executioner caspases in the course of apoptosis, does not exert true cytoprotective effects in the mammalian system, but simply alters the kinetics of cellular demise as it shifts its morphologic and biochemical correlates. Conversely, bona fide cytoprotection can be achieved by inhibiting the transduction of lethal signals in the early phases of the process, when adaptive responses are still operational. Thus, the mechanisms that truly execute RCD may be less understood, less inhibitable and perhaps more homogeneous than previously thought. Here, the Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death.
2015
Online ahead of print
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/06 - ANATOMIA COMPARATA E CITOLOGIA
Settore BIO/10 - BIOCHIMICA
Settore BIO/11 - BIOLOGIA MOLECOLARE
Settore BIO/17 - ISTOLOGIA
Settore BIO/13 - BIOLOGIA APPLICATA
English
Con Impact Factor ISI
Animals; Humans; Terminology as Topic; Apoptosis; Signal Transduction
Cell Death and Differentiation (2015) 22, 58–73; published online 19 September 2014
Galluzzi, L., Bravo San Pedro, J., Vitale, A., Aaronson, S., Abrams, J., Adam, D., et al. (2015). Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. CELL DEATH AND DIFFERENTIATION, 22(1), 58-73 [10.1038/cdd.2014.137].
Galluzzi, L; Bravo San Pedro, J; Vitale, A; Aaronson, S; Abrams, J; Adam, D; Alnemri, E; Altucci, L; Andrews, D; Annicchiarico Petruzzelli, M; Baehrec...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/93607
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