Mitochondria produce the bulk of cellular energy and work as decisional "hubs" for cellular responses by integrating different input signals. The determinant in the physiopathology of mammals, they attract major attention, nowadays, for their contribution to brain degeneration. How they can withstand or succumb to insults leading to neuronal death is an object of great attention increasing the need for a better understanding of the interplay between inner and outer mitochondrial pathways residing in the cytosol. Of the latter, those dictating protein metabolism and therefore influencing the quality function and control of the organelle are of our most immediate interest and here we describe the Transglutaminase type 2 (TG2) contribution to mitochondrial function, dysfunction and neurodegeneration. Besides reviewing the latest evidences we share also the novel ones on the IF1 pathway depicting a molecular conduit governing mitochondrial turnover and homeostasis relevant to envisaging preventive and therapeutic strategies to respectively predict and counteract deficiencies associated with deregulated mitochondrial function in neuropathology.

Altuntas, S., D'Eletto, M., Rossin, F., Hidalgo, L., Farrace, M.g., Falasca, L., et al. (2014). Transglutaminase type 2, mitochondria and Huntington's disease: Menage a trois. MITOCHONDRION [10.1016/j.mito.2014.09.008].

Transglutaminase type 2, mitochondria and Huntington's disease: Menage a trois.

Rossin, F;FARRACE, MARIA GRAZIA;PIREDDA, LUCIA;PIACENTINI, MAURO;
2014-09-28

Abstract

Mitochondria produce the bulk of cellular energy and work as decisional "hubs" for cellular responses by integrating different input signals. The determinant in the physiopathology of mammals, they attract major attention, nowadays, for their contribution to brain degeneration. How they can withstand or succumb to insults leading to neuronal death is an object of great attention increasing the need for a better understanding of the interplay between inner and outer mitochondrial pathways residing in the cytosol. Of the latter, those dictating protein metabolism and therefore influencing the quality function and control of the organelle are of our most immediate interest and here we describe the Transglutaminase type 2 (TG2) contribution to mitochondrial function, dysfunction and neurodegeneration. Besides reviewing the latest evidences we share also the novel ones on the IF1 pathway depicting a molecular conduit governing mitochondrial turnover and homeostasis relevant to envisaging preventive and therapeutic strategies to respectively predict and counteract deficiencies associated with deregulated mitochondrial function in neuropathology.
28-set-2014
In corso di stampa
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/06 - ANATOMIA COMPARATA E CITOLOGIA
English
Con Impact Factor ISI
IF(1); Mitochondria; Mitophagy; Neurodegeneration; TG2
Altuntas, S., D'Eletto, M., Rossin, F., Hidalgo, L., Farrace, M.g., Falasca, L., et al. (2014). Transglutaminase type 2, mitochondria and Huntington's disease: Menage a trois. MITOCHONDRION [10.1016/j.mito.2014.09.008].
Altuntas, S; D'Eletto, M; Rossin, F; Hidalgo, L; Farrace, Mg; Falasca, L; Piredda, L; Cocco, S; Mastroberardino, P; Piacentini, M; Campanella, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/93587
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