We report that the third intron of the L1 ribosomal protein gene of Xenopus laevis encodes a previously uncharacterized small nucleolar RNA that we called U16. This snRNA is not independently transcribed; instead it originates by processing of the pre-mRNA in which it is contained. Its sequence, localization and biosynthesis are phylogenetically conserved: in the corresponding intron of the human L1 ribosomal protein gene a highly homologous region is found which can be released from the pre-mRNA by a mechanism similar to that described for the amphibian U16 RNA. The presence of a snoRNA inside an intron of the L1 ribosomal protein gene and the phylogenetic conservation of this gene arrangement suggest an important regulatory/functional link between these two components.

Fragapane, P., Prislei, S., Michienzi, A., Caffarelli, E., Bozzoni, I. (1993). A novel small nucleolar RNA (U16) is encoded inside a ribosomal protein intron and originates by processing of the pre-mRNA. EMBO JOURNAL, 12(7), 2921-2928.

A novel small nucleolar RNA (U16) is encoded inside a ribosomal protein intron and originates by processing of the pre-mRNA

MICHIENZI, ALESSANDRO;
1993-07-01

Abstract

We report that the third intron of the L1 ribosomal protein gene of Xenopus laevis encodes a previously uncharacterized small nucleolar RNA that we called U16. This snRNA is not independently transcribed; instead it originates by processing of the pre-mRNA in which it is contained. Its sequence, localization and biosynthesis are phylogenetically conserved: in the corresponding intron of the human L1 ribosomal protein gene a highly homologous region is found which can be released from the pre-mRNA by a mechanism similar to that described for the amphibian U16 RNA. The presence of a snoRNA inside an intron of the L1 ribosomal protein gene and the phylogenetic conservation of this gene arrangement suggest an important regulatory/functional link between these two components.
lug-1993
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/13 - BIOLOGIA APPLICATA
English
Con Impact Factor ISI
processing, post-transcriptional; rna precursors; ribosomal proteins; ribonucleoproteins; dna; conserved sequence; base sequence; animals; introns; humans; rna, messenger; rna, small nuclear; chromosomal proteinsnon-histone; molecular sequence data; nucleic acid hybridization; transcription, genetic; xenopus laevis
Fragapane, P., Prislei, S., Michienzi, A., Caffarelli, E., Bozzoni, I. (1993). A novel small nucleolar RNA (U16) is encoded inside a ribosomal protein intron and originates by processing of the pre-mRNA. EMBO JOURNAL, 12(7), 2921-2928.
Fragapane, P; Prislei, S; Michienzi, A; Caffarelli, E; Bozzoni, I
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/9344
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