Several studies point to the existence of an inverse correlation between cellular lipid peroxidation and both cell proliferation and neoplastic transformation. In anaplastic cell lines products of membrane lipid peroxidation are very low or undetectable. Furthermore numerous results demonstrate effect of lipid peroxidation products on central biochemical pathways and intracellular signalling at physiological concentrations. 4-hydroxynonenal (HNE) is one of the most active products of lipid peroxidation. The restoration of HNE physiological concentrations in neoplastic cells may inhibit cell proliferation and modulate cell re-differentiation. This review try to summarize and critically discuss the effects of physiological concentrations of HNE on normal and neoplastic cell line.
Fazio, V.M., Rinaldi, M., Ciafrè, S., Barrera, G., & Farace, M.G. (1993). Control of neoplastic cell proliferation and differentiation by restoration of 4-hydroxynonenal physiological concentrations. MOLECULAR ASPECTS OF MEDICINE, 14(3), 217-228.
Tipologia: | Articolo su rivista |
Citazione: | Fazio, V.M., Rinaldi, M., Ciafrè, S., Barrera, G., & Farace, M.G. (1993). Control of neoplastic cell proliferation and differentiation by restoration of 4-hydroxynonenal physiological concentrations. MOLECULAR ASPECTS OF MEDICINE, 14(3), 217-228. |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore BIO/13 |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 1993 |
Titolo: | Control of neoplastic cell proliferation and differentiation by restoration of 4-hydroxynonenal physiological concentrations |
Autori: | |
Autori: | Fazio, VM; Rinaldi, M; Ciafrè, S; Barrera, G; Farace, MG |
Appare nelle tipologie: | 01 - Articolo su rivista |