The same factor, ABF1, binds to the promoters of the two gene copies (L2A and L2B) coding for the ribosomal protein L2 in Saccharomyces cerevisiae. In vitro binding experiments and in vivo functional analysis showed that the different affinities of the L2A and L2B promoters for the ABF1 factor are responsible for the differential transcriptional activities of the two gene copies. The presence of ABF1-binding sites in front of many housekeeping genes suggests a general role for ABF1 in the regulation of gene activity.

Della Seta, F., Ciafre', S.a., Marck, C., Santoro, B., Presutti, C., Sentenac, A., et al. (1990). The ABF1 factor is the transcriptional activator of the L2 ribosomal protein genes in Saccharomyces cerevisiae. MOLECULAR AND CELLULAR BIOLOGY, 10(5), 2437-2441.

The ABF1 factor is the transcriptional activator of the L2 ribosomal protein genes in Saccharomyces cerevisiae

CIAFRE', SILVIA ANNA;
1990-05-01

Abstract

The same factor, ABF1, binds to the promoters of the two gene copies (L2A and L2B) coding for the ribosomal protein L2 in Saccharomyces cerevisiae. In vitro binding experiments and in vivo functional analysis showed that the different affinities of the L2A and L2B promoters for the ABF1 factor are responsible for the differential transcriptional activities of the two gene copies. The presence of ABF1-binding sites in front of many housekeeping genes suggests a general role for ABF1 in the regulation of gene activity.
mag-1990
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/13 - BIOLOGIA APPLICATA
English
Con Impact Factor ISI
Saccharomyces cerevisiae; Gene Expression Regulation, Fungal; Regulatory Sequences, Nucleic Acid; Ribosomal Proteins; DNA, Fungal; Transcription Factors; Restriction Mapping; Base Sequence; Promoter Regions, Genetic; Molecular Sequence Data; Fungal Proteins; Transcription, Genetic
Della Seta, F., Ciafre', S.a., Marck, C., Santoro, B., Presutti, C., Sentenac, A., et al. (1990). The ABF1 factor is the transcriptional activator of the L2 ribosomal protein genes in Saccharomyces cerevisiae. MOLECULAR AND CELLULAR BIOLOGY, 10(5), 2437-2441.
Della Seta, F; Ciafre', Sa; Marck, C; Santoro, B; Presutti, C; Sentenac, A; Bozzoni, I
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/9186
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