Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictor peptide isolated from the culture supernatant of porcine aortic endothelial cells. This 21 amino-acid residue peptide has potent vasoconstrictive properties in vitro and in vivo. ET-1 action involves phosphatidylinositol turnover, calcium mobilization and protein kinase C activation. Endothelial cells have distinct receptors for different operating through hydrosoluble hormones. The aim of this study was to investigate on a possible role of angiotensin II (ANG II) to modulate the release ET-1 from human endothelial cells in vitro. These data revealed a time- and a dose-dependent increase of ET-1 production in response to ANG II. This mechanism may have important pathophysiological implications in vivo. In fact, a double-mechanism of secretion of ET-1 from endothelial cells could exist: one active in a physiological condition and an other in response to a vasoconstrictor stimuli (as well as ANG II). Furthermore, these results may suggest an additional favourable effect of ACE-inhibition in human hypertension therapy.

Ciafré, S.A., D'Armiento, F.P., Di Gregorio, F., Colasanti, P., Di Benedetto, A., Langella, A., et al. (1993). Angiotensin II stimulates endothelin-1 release from human endothelial cells. RECENTI PROGRESSI IN MEDICINA, 84(4), 248-253.

Angiotensin II stimulates endothelin-1 release from human endothelial cells

CIAFRE', SILVIA ANNA;
1993-04

Abstract

Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictor peptide isolated from the culture supernatant of porcine aortic endothelial cells. This 21 amino-acid residue peptide has potent vasoconstrictive properties in vitro and in vivo. ET-1 action involves phosphatidylinositol turnover, calcium mobilization and protein kinase C activation. Endothelial cells have distinct receptors for different operating through hydrosoluble hormones. The aim of this study was to investigate on a possible role of angiotensin II (ANG II) to modulate the release ET-1 from human endothelial cells in vitro. These data revealed a time- and a dose-dependent increase of ET-1 production in response to ANG II. This mechanism may have important pathophysiological implications in vivo. In fact, a double-mechanism of secretion of ET-1 from endothelial cells could exist: one active in a physiological condition and an other in response to a vasoconstrictor stimuli (as well as ANG II). Furthermore, these results may suggest an additional favourable effect of ACE-inhibition in human hypertension therapy.
Pubblicato
Rilevanza nazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/13
Italian
Time Factors; Stimulation, Chemical; Cells, Cultured; Iodine Radioisotopes; Endothelium, Vascular; Dose-Response Relationship, Drug; Angiotensin II; Receptors, Angiotensin; Endothelins; Humans
Ciafré, S.A., D'Armiento, F.P., Di Gregorio, F., Colasanti, P., Di Benedetto, A., Langella, A., et al. (1993). Angiotensin II stimulates endothelin-1 release from human endothelial cells. RECENTI PROGRESSI IN MEDICINA, 84(4), 248-253.
Ciafre', Sa; D'Armiento, F; Di Gregorio, F; Colasanti, P; Di Benedetto, A; Langella, A; Di Ieso, N; Liguori, A; Colasanti, R; Napoli, C
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/9176
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