Since February 2002, the Drug Resources Enhancement against AIDS and Malnutrition Program has provided highly active antiretroviral therapy (HAART) and immunologic and virologic monitoring free of charge. We conducted a cohort study of persons infected with human immunodeficiency virus in Mozambique. Only persons treated with HAART with available CD4 cell counts at baseline and ≥ 1 CD4 cell count after HAART were included. Survival analysis was applied to evaluate the prognostic value of CD4 cell counts measured at three months. Possible confounders were considered. A total of 753 persons who started HAART included; 59% were females. Median age was 34 years (range = 16-67 years), and the median CD4 cell count at baseline was 172 cells/mm3 (interquartile range = 87-261 cells/mm3, range = 0-1,322 cells/mm3). Overall, 105 persons (14%) died. Of these persons 54 (51%) developed AIDS before they died; 25 (3%) died during the first three months. After three months of therapy, the individual median CD4 cell count change from the baseline value was +101 cells/mm3 (interquartile range = +27 to +187 cells/mm3, range = -723 to +310 cells/mm3). A median CD4 increment of 100 cells/mm3 in three months was associated with a mortality reduction of 50% compared with an increase of < 50 cells (relative hazard of death adjusted for baseline CD4 cell count = 0.54, 95% confidence interval = 0.30-0.95). A good initial response to HAART was associated with a significant reduction of mortality. This finding supports the effectiveness of HAART in resource-poor settings.
Palombi, L., Dorrucci, M., Zimba, I., Scarcella, P., Mancinelli, S., Buonomo, E., et al. (2010). Immunologic response to highly active antiretroviral therapy and mortality reduction in a cohort of human immunodeficiency virus-positive persons in Mozambique. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 83(5), 1128-1132.
Tipologia: | Articolo su rivista |
Citazione: | Palombi, L., Dorrucci, M., Zimba, I., Scarcella, P., Mancinelli, S., Buonomo, E., et al. (2010). Immunologic response to highly active antiretroviral therapy and mortality reduction in a cohort of human immunodeficiency virus-positive persons in Mozambique. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 83(5), 1128-1132. |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore MED/42 - Igiene Generale e Applicata |
Revisione (peer review): | Esperti anonimi |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.4269/ajtmh.2010.09-0705 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | nov-2010 |
Titolo: | Immunologic response to highly active antiretroviral therapy and mortality reduction in a cohort of human immunodeficiency virus-positive persons in Mozambique |
Autori: | |
Autori: | Palombi, L; Dorrucci, M; Zimba, I; Scarcella, P; Mancinelli, S; Buonomo, E; Guidotti, G; Marazzi, MC; Rezza, G |
Appare nelle tipologie: | 01 - Articolo su rivista |
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