Aloin, a natural anthracycline from aloe plant, is a hydroxyanthraquinone derivative shown to have antitumor properties. This study demonstrated that aloin exerted inhibition of cell proliferation, adhesion and invasion abilities of B16-F10 melanoma cells under non-cytotoxic concentrations. Furthermore, aloin induced melanoma cell differentiation through the enhancement of melanogenesis and transglutaminase activity. To improve the growth-inhibiting effect of anticancer agents, we found that the combined treatment of cells with aloin and low doses of cisplatin increases the antiproliferative activity of aloin. The results suggest that aloin possesses antineoplastic and antimetastatic properties, exerted likely through the induction of melanoma cell differentiation.

Tabolacci, C., Rossi, S., Lentini, A., Provenzano, B., Turcano, L., Facchiano, F., et al. (2013). Aloin enhances cisplatin antineoplastic activity in B16-F10 melanoma cells by transglutaminase-induced differentiation. AMINO ACIDS, 44(1), 293-300 [10.1007/s00726-011-1166-x].

Aloin enhances cisplatin antineoplastic activity in B16-F10 melanoma cells by transglutaminase-induced differentiation

LENTINI, ALESSANDRO;PROVENZANO, BRUNO;BENINATI, SIMONE
2013-01-01

Abstract

Aloin, a natural anthracycline from aloe plant, is a hydroxyanthraquinone derivative shown to have antitumor properties. This study demonstrated that aloin exerted inhibition of cell proliferation, adhesion and invasion abilities of B16-F10 melanoma cells under non-cytotoxic concentrations. Furthermore, aloin induced melanoma cell differentiation through the enhancement of melanogenesis and transglutaminase activity. To improve the growth-inhibiting effect of anticancer agents, we found that the combined treatment of cells with aloin and low doses of cisplatin increases the antiproliferative activity of aloin. The results suggest that aloin possesses antineoplastic and antimetastatic properties, exerted likely through the induction of melanoma cell differentiation.
gen-2013
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/06 - ANATOMIA COMPARATA E CITOLOGIA
Settore MED/04 - PATOLOGIA GENERALE
English
Cell Movement; Animals; Spermine; Monophenol Monooxygenase; Antineoplastic Agents; Melanoma, Experimental; Transglutaminases; Cell Differentiation; Cell Line, Tumor; Mice; Cell Proliferation; Cisplatin; Emodin; Drug Synergism; Melanins; Cell Adhesion
Tabolacci, C., Rossi, S., Lentini, A., Provenzano, B., Turcano, L., Facchiano, F., et al. (2013). Aloin enhances cisplatin antineoplastic activity in B16-F10 melanoma cells by transglutaminase-induced differentiation. AMINO ACIDS, 44(1), 293-300 [10.1007/s00726-011-1166-x].
Tabolacci, C; Rossi, S; Lentini, A; Provenzano, B; Turcano, L; Facchiano, F; Beninati, S
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/91549
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