Apaf1 (apoptotic protease activating factor 1) is the central component of the apoptosome, a multiprotein complex that activates procaspase-9 after cytochrome c release from the mitochondria in the intrinsic pathway of apoptosis. Other cellular roles, including a pro-survival role, have also been described for Apaf1, while the relative contribution of each function to cell death, but also to cell homeostatic conditions, remain to be clarified.

Sancho, M., Gortat, A., Herrera, A., Andreu Fernández, V., Ferraro, E., Cecconi, F., et al. (2014). Altered mitochondria morphology and cell metabolism in Apaf1-deficient cells. PLOS ONE, 9, e84666-e84666-- [10.1371/journal.pone.0084666].

Altered mitochondria morphology and cell metabolism in Apaf1-deficient cells

CECCONI, FRANCESCO;
2014-01-01

Abstract

Apaf1 (apoptotic protease activating factor 1) is the central component of the apoptosome, a multiprotein complex that activates procaspase-9 after cytochrome c release from the mitochondria in the intrinsic pathway of apoptosis. Other cellular roles, including a pro-survival role, have also been described for Apaf1, while the relative contribution of each function to cell death, but also to cell homeostatic conditions, remain to be clarified.
2014
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/06 - ANATOMIA COMPARATA E CITOLOGIA
English
Con Impact Factor ISI
Sancho, M., Gortat, A., Herrera, A., Andreu Fernández, V., Ferraro, E., Cecconi, F., et al. (2014). Altered mitochondria morphology and cell metabolism in Apaf1-deficient cells. PLOS ONE, 9, e84666-e84666-- [10.1371/journal.pone.0084666].
Sancho, M; Gortat, A; Herrera, A; Andreu Fernández, V; Ferraro, E; Cecconi, F; Orzáez, M; Pérez Payá, E
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/91482
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