Atrial natriuretic peptide (ANP) is a hormone, produced mainly by cardiomyocytes, with a major role in cardiovascular homeostatic mechanisms such as natriuresis and vasodilation, which serve to regulate blood pressure. However, ANP also acts as an autocrine/paracrine factor on other targets such as kidney, lung, thymus, liver and the immune system. ANP participates in the regulation of cell growth and proliferation, and evidence is accumulating that these effects are associated with the generation of reactive oxygen species (ROS). In vascular cells and cardiomyocytes ANP stimulates the antioxidant defense, but in other systems such as hepatoblastoma and macrophages ANP may produce either antioxidant or prooxidant effects, depending on experimental conditions and cell context. At present very little is known on the relationship between ANP and ROS production in the normal homeostatic processes or during the development of cardiovascular diseases and cancer. Our current knowledge of the role of ANP in signaling pathways leading to the generation of intracellular messengers such as diacylglycerol (DAG), and guanosine 3'-5'-cyclic monophosphate has been examined in order to clarify the mechanisms by which the hormone may counteract or contribute to the potentially dangerous effects of free radicals.

DE VITO, P., Incerpi, S., Pedersen, J.z., Luly, P. (2010). Atrial natriuretic peptide and oxidative stress. PEPTIDES, 31(7), 1412-1419 [10.1016/j.peptides.2010.04.001].

Atrial natriuretic peptide and oxidative stress

DE VITO, PAOLO;PEDERSEN, JENS ZACHO;LULY, PAOLO
2010-07-01

Abstract

Atrial natriuretic peptide (ANP) is a hormone, produced mainly by cardiomyocytes, with a major role in cardiovascular homeostatic mechanisms such as natriuresis and vasodilation, which serve to regulate blood pressure. However, ANP also acts as an autocrine/paracrine factor on other targets such as kidney, lung, thymus, liver and the immune system. ANP participates in the regulation of cell growth and proliferation, and evidence is accumulating that these effects are associated with the generation of reactive oxygen species (ROS). In vascular cells and cardiomyocytes ANP stimulates the antioxidant defense, but in other systems such as hepatoblastoma and macrophages ANP may produce either antioxidant or prooxidant effects, depending on experimental conditions and cell context. At present very little is known on the relationship between ANP and ROS production in the normal homeostatic processes or during the development of cardiovascular diseases and cancer. Our current knowledge of the role of ANP in signaling pathways leading to the generation of intracellular messengers such as diacylglycerol (DAG), and guanosine 3'-5'-cyclic monophosphate has been examined in order to clarify the mechanisms by which the hormone may counteract or contribute to the potentially dangerous effects of free radicals.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/09
English
Con Impact Factor ISI
Reactive Oxygen Species; NADPH Oxidase; Oxidative Stress; Cyclic GMP; Receptors, Atrial Natriuretic Factor; Atrial Natriuretic Factor; Animals; Humans
DE VITO, P., Incerpi, S., Pedersen, J.z., Luly, P. (2010). Atrial natriuretic peptide and oxidative stress. PEPTIDES, 31(7), 1412-1419 [10.1016/j.peptides.2010.04.001].
DE VITO, P; Incerpi, S; Pedersen, Jz; Luly, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/9145
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