The development of atherosclerotic lesions associates with the proliferation of vascular smooth muscle cells (VSMC), and their migration from arterial tunica media to the intima. Fibroblast growth factor (FGF)-2 can trigger either phenomena, which are accompanied by the functional impairment of the p53 transcription factor. However, FGF-2 impact on p53 function in VSMC is largely unknown.

Barillari, G., Iovane, A., Bonuglia, M., ALBONICI BOVE, L., Garofano, P., Di Campli, E., et al. (2010). Fibroblast growth factor-2 transiently activates the p53 oncosuppressor protein in human primary vascular smooth muscle cells: implications for atherogenesis. ATHEROSCLEROSIS, 210(2), 400-406 [10.1016/j.atherosclerosis.2010.01.006].

Fibroblast growth factor-2 transiently activates the p53 oncosuppressor protein in human primary vascular smooth muscle cells: implications for atherogenesis

BARILLARI, GIOVANNI;ALBONICI BOVE, LOREDANA;MANZARI, VITTORIO;
2010-06-01

Abstract

The development of atherosclerotic lesions associates with the proliferation of vascular smooth muscle cells (VSMC), and their migration from arterial tunica media to the intima. Fibroblast growth factor (FGF)-2 can trigger either phenomena, which are accompanied by the functional impairment of the p53 transcription factor. However, FGF-2 impact on p53 function in VSMC is largely unknown.
giu-2010
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/04 - PATOLOGIA GENERALE
Settore MED/05 - PATOLOGIA CLINICA
Settore MED/46 - SCIENZE TECNICHE DI MEDICINA E DI LABORATORIO
English
Con Impact Factor ISI
atherosclerosis; cells, cultured; tumor suppressor protein p53; blotting, western; proto-oncogene proteins c-mdm2; humans; reverse transcriptase polymerase chain reaction; thrombospondin 1; models, biological; phosphorylation; fibroblast growth Factor 2; cell movement; muscle, smooth, vascular; cytoplasm
Barillari, G., Iovane, A., Bonuglia, M., ALBONICI BOVE, L., Garofano, P., Di Campli, E., et al. (2010). Fibroblast growth factor-2 transiently activates the p53 oncosuppressor protein in human primary vascular smooth muscle cells: implications for atherogenesis. ATHEROSCLEROSIS, 210(2), 400-406 [10.1016/j.atherosclerosis.2010.01.006].
Barillari, G; Iovane, A; Bonuglia, M; ALBONICI BOVE, L; Garofano, P; Di Campli, E; Falchi, M; Condò, I; Manzari, V; Ensoli, B
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/9128
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