On the basis of a large body of experimental data the notion that glaucoma damages retinal ganglion cells and central areas of the visual system has been put forward. The mechanisms underlying glaucomatous involvement of the central areas are not known: the most likely hypothesis is that this event is the result of an anterograde transynaptic neurodegeneration triggered by ganglion cells' death. However, it is possible that in some cases it may be the consequence of a neurodegenerative disease of the central nervous system. In any event, novel mechanisms leading to cell demise might be implicated. The development of powerful neuroimaging techniques in conjunction with sophisticated analysis has recently provided compelling support to the involvement of central stations of the visual pathway in patients suffering of glaucoma. Diffusion Tensor-MRI allows the central damage associated with glaucoma to be assessed and therapeutic efficacy of novel neuroprotective interventions to be quantified. © 2012 Elsevier Ltd.
Nucci, C., Martucci, A., Cesareo, M., Mancino, R., Russo, R., Bagetta, G., et al. (2013). Brain involvement in glaucoma: Advanced neuroimaging for understanding and monitoring a new target for therapy. CURRENT OPINION IN PHARMACOLOGY, 13(1), 128-133 [10.1016/j.coph.2012.08.004].
Brain involvement in glaucoma: Advanced neuroimaging for understanding and monitoring a new target for therapy
NUCCI, CARLO;Martucci, A;CESAREO, MASSIMO;MANCINO, RAFFAELE;CERULLI, LUCIANO;GARACI, FRANCESCO
2013-01-01
Abstract
On the basis of a large body of experimental data the notion that glaucoma damages retinal ganglion cells and central areas of the visual system has been put forward. The mechanisms underlying glaucomatous involvement of the central areas are not known: the most likely hypothesis is that this event is the result of an anterograde transynaptic neurodegeneration triggered by ganglion cells' death. However, it is possible that in some cases it may be the consequence of a neurodegenerative disease of the central nervous system. In any event, novel mechanisms leading to cell demise might be implicated. The development of powerful neuroimaging techniques in conjunction with sophisticated analysis has recently provided compelling support to the involvement of central stations of the visual pathway in patients suffering of glaucoma. Diffusion Tensor-MRI allows the central damage associated with glaucoma to be assessed and therapeutic efficacy of novel neuroprotective interventions to be quantified. © 2012 Elsevier Ltd.File | Dimensione | Formato | |
---|---|---|---|
curr opin NUCCI def.pdf
solo utenti autorizzati
Licenza:
Copyright dell'editore
Dimensione
479.54 kB
Formato
Adobe PDF
|
479.54 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.