On the basis of a large body of experimental data the notion that glaucoma damages retinal ganglion cells and central areas of the visual system has been put forward. The mechanisms underlying glaucomatous involvement of the central areas are not known: the most likely hypothesis is that this event is the result of an anterograde transynaptic neurodegeneration triggered by ganglion cells' death. However, it is possible that in some cases it may be the consequence of a neurodegenerative disease of the central nervous system. In any event, novel mechanisms leading to cell demise might be implicated. The development of powerful neuroimaging techniques in conjunction with sophisticated analysis has recently provided compelling support to the involvement of central stations of the visual pathway in patients suffering of glaucoma. Diffusion Tensor-MRI allows the central damage associated with glaucoma to be assessed and therapeutic efficacy of novel neuroprotective interventions to be quantified. © 2012 Elsevier Ltd.

Nucci, C., Martucci, A., Cesareo, M., Mancino, R., Russo, R., Bagetta, G., et al. (2013). Brain involvement in glaucoma: Advanced neuroimaging for understanding and monitoring a new target for therapy. CURRENT OPINION IN PHARMACOLOGY, 13(1), 128-133 [10.1016/j.coph.2012.08.004].

Brain involvement in glaucoma: Advanced neuroimaging for understanding and monitoring a new target for therapy

NUCCI, CARLO;CESAREO, MASSIMO;MANCINO, RAFFAELE;CERULLI, LUCIANO;GARACI, FRANCESCO
2013-01-01

Abstract

On the basis of a large body of experimental data the notion that glaucoma damages retinal ganglion cells and central areas of the visual system has been put forward. The mechanisms underlying glaucomatous involvement of the central areas are not known: the most likely hypothesis is that this event is the result of an anterograde transynaptic neurodegeneration triggered by ganglion cells' death. However, it is possible that in some cases it may be the consequence of a neurodegenerative disease of the central nervous system. In any event, novel mechanisms leading to cell demise might be implicated. The development of powerful neuroimaging techniques in conjunction with sophisticated analysis has recently provided compelling support to the involvement of central stations of the visual pathway in patients suffering of glaucoma. Diffusion Tensor-MRI allows the central damage associated with glaucoma to be assessed and therapeutic efficacy of novel neuroprotective interventions to be quantified. © 2012 Elsevier Ltd.
2013
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
Settore MED/30 - MALATTIE APPARATO VISIVO
English
n methyl dextro aspartic acid; neuronal nitric oxide synthase; nitric oxide; parvalbumin, article; brain damage; brain disease; central nervous system disease; degenerative disease; diffusion tensor imaging; DNA fragmentation; fractional anisotropy; glaucoma; human; intraocular pressure; lateral geniculate body; neuroimaging; neuroprotection; nonhuman; nuclear magnetic resonance imaging; optic nerve disease; prevalence; priority journal; protein expression; refraction error; retina ganglion cell; signal transduction; visual cortex, Animals; Brain; Central Nervous System Diseases; Glaucoma; Humans; Neurodegenerative Diseases; Neuroimaging; Neurons
Nucci, C., Martucci, A., Cesareo, M., Mancino, R., Russo, R., Bagetta, G., et al. (2013). Brain involvement in glaucoma: Advanced neuroimaging for understanding and monitoring a new target for therapy. CURRENT OPINION IN PHARMACOLOGY, 13(1), 128-133 [10.1016/j.coph.2012.08.004].
Nucci, C; Martucci, A; Cesareo, M; Mancino, R; Russo, R; Bagetta, G; Cerulli, L; Garaci, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/90312
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