Reduced insulin clearance has been shown to predict the development of type 2 diabetes. Recently, it has been suggested that plasma glucose concentrations ≥ 8.6 mmol/l (155 mg/dl) at 1 h during an oral glucose tolerance test (OGTT) can identify individuals at high risk for type 2 diabetes among those who have normal glucose tolerance (NGT 1 h-high). The aim of this study was to examine whether NGT 1 h-high have a decrease in insulin clearance, as compared with NGT individuals with 1-h post-load glucose <8.6 mmol/l (l (155 mg/dl, NGT 1 h-low). To this end, 438 non-diabetic White individuals were subjected to OGTT and euglycemic-hyperinsulinemic clamp to evaluate insulin clearance and insulin sensitivity. As compared with NGT 1 h-low individuals, NGT 1 h-high had significantly higher 1-h and 2-h post-load plasma glucose and 2-h insulin levels as well as higher fasting glucose and insulin levels. NGT 1 h-high exhibited also a significant decrease in both insulin sensitivity (P<0.0001) and insulin clearance (P = 0.006) after adjusting for age, gender, adiposity measures, and insulin sensitivity. The differences in insulin clearance remained significant after adjustment for fasting glucose (P = 0.02) in addition to gender, age, and BMI. In univariate analyses adjusted for gender and age, insulin clearance was inversely correlated with body weight, body mass index, waist, fat mass, 1-h and 2-h post-load glucose levels, fasting, 1-h and 2-h post-load insulin levels, and insulin-stimulated glucose disposal. In conclusion, our data show that NGT 1 h-high have a reduction in insulin clearance as compared with NGT 1 h-low individuals; this suggests that impaired insulin clearance may contribute to sustained fasting and post-meal hyperinsulinemia.
Marini, M., Frontoni, S., Succurro, E., Arturi, F., Fiorentino, T., Sciacqua, A., et al. (2013). Decreased insulin clearance in individuals with elevated 1-h post-load plasma glucose levels. PLOS ONE, 8(10), e77440-e77440.
|Tipologia:||Articolo su rivista|
|Citazione:||Marini, M., Frontoni, S., Succurro, E., Arturi, F., Fiorentino, T., Sciacqua, A., et al. (2013). Decreased insulin clearance in individuals with elevated 1-h post-load plasma glucose levels. PLOS ONE, 8(10), e77440-e77440.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1371/journal.pone.0077440|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2013|
|Titolo:||Decreased insulin clearance in individuals with elevated 1-h post-load plasma glucose levels|
|Autori:||Marini, M; Frontoni, S; Succurro, E; Arturi, F; Fiorentino, T; Sciacqua, A; Hribal, M; Perticone, F; Sesti, G|
|Appare nelle tipologie:||01 - Articolo su rivista|