Serotonergic (5-hydroxytryptamine; 5-HT) transmission has been implicated in the pathogenesis of Alzheimer's disease (AD). A coding single nucleotide polymorphism 267 (C/T) in the 5-HT(6) receptor gene was previously reported as a susceptibility factor for AD. An extensive replication study was performed using our data set including sporadic and familial cases. No significant association between the 5-HT(6) receptor gene and AD was obtained with or without the stratification of apolipoprotein E epsilon 4 status. Our result suggests that the 267C allele of the 5-HT(6) receptor gene may not be a genetic risk factor for AD.
Orlacchio, A., Kawarai, T., Paciotti, E., Stefani, A., Orlacchio, A., Sorbi, S., et al. (2002). Association study of the 5-hydroxytryptamine(6) receptor gene in Alzheimer's disease. NEUROSCIENCE LETTERS, 325(1), 13-16.
Association study of the 5-hydroxytryptamine(6) receptor gene in Alzheimer's disease
ORLACCHIO, ANTONIO;STEFANI, ALESSANDRO;ORLACCHIO, ANTONIO;BERNARDI, GIORGIO
2002-05-31
Abstract
Serotonergic (5-hydroxytryptamine; 5-HT) transmission has been implicated in the pathogenesis of Alzheimer's disease (AD). A coding single nucleotide polymorphism 267 (C/T) in the 5-HT(6) receptor gene was previously reported as a susceptibility factor for AD. An extensive replication study was performed using our data set including sporadic and familial cases. No significant association between the 5-HT(6) receptor gene and AD was obtained with or without the stratification of apolipoprotein E epsilon 4 status. Our result suggests that the 267C allele of the 5-HT(6) receptor gene may not be a genetic risk factor for AD.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
