Dual/mixed-tropic HIV-1 strains are predominant in a significant proportion of patients, though little information is available regarding their replication-capacity and susceptibility against CCR5-antagonists in-vitro. The aim of the study was to analyze the replication-capacity and susceptibility to maraviroc of HIV-1 clinical isolates with different tropism characteristics in primary monocyte-derived-macrophages (MDM), peripheral-blood-mononuclear-cells (PBMC), and CD4(+) T-lymphocytes.
Surdo, M., Balestra, E., Saccomandi, P., DI SANTO, F., Montano, M., Di Carlo, D., et al. (2013). Inhibition of dual/mixed tropic HIV-1 isolates by CCR5-inhibitors in primary lymphocytes and macrophages. PLOS ONE, 8(7), e68076-e68076 [10.1371/journal.pone.0068076].
Inhibition of dual/mixed tropic HIV-1 isolates by CCR5-inhibitors in primary lymphocytes and macrophages
BALESTRA, EMANUELA;SACCOMANDI, PATRIZIA;DI SANTO, FABIOLA;MONTANO, MARCO;SARMATI, LOREDANA;AQUARO, STEFANO;ANDREONI, MASSIMO;SVICHER, VALENTINA;PERNO, CARLO FEDERICO;CECCHERINI SILBERSTEIN, FRANCESCA
2013-07-09
Abstract
Dual/mixed-tropic HIV-1 strains are predominant in a significant proportion of patients, though little information is available regarding their replication-capacity and susceptibility against CCR5-antagonists in-vitro. The aim of the study was to analyze the replication-capacity and susceptibility to maraviroc of HIV-1 clinical isolates with different tropism characteristics in primary monocyte-derived-macrophages (MDM), peripheral-blood-mononuclear-cells (PBMC), and CD4(+) T-lymphocytes.| File | Dimensione | Formato | |
|---|---|---|---|
|
2013_Inhibition of dualmixed tropic_plosone_Surdo.pdf
accesso aperto
Licenza:
Creative commons
Dimensione
556.82 kB
Formato
Adobe PDF
|
556.82 kB | Adobe PDF | Visualizza/Apri |
Questo articolo è pubblicato sotto una Licenza Licenza Creative Commons
