Whether IGF-1 has a protective or a detrimental role in vascular homeostasis remains unsettled. There is evidence that the C/T polymorphism rs35767 near the promoter region of the IGF1 gene located in chromosome 12 is associated with plasma IGF-1 levels. We investigated the effects of this polymorphism on circulating IGF-1 levels, carotid intima media thickness (cIMT) and endothelial-dependent vasodilation.

Sesti, G., Mannino, G., Andreozzi, F., Greco, A., Perticone, M., Sciacqua, A., et al. (2014). A polymorphism at IGF1 locus is associated with carotid intima media thickness and endothelium-dependent vasodilatation. ATHEROSCLEROSIS, 232(1), 25-30 [10.1016/j.atherosclerosis.2013.10.024].

A polymorphism at IGF1 locus is associated with carotid intima media thickness and endothelium-dependent vasodilatation

MARINI, MARIA ADELAIDE;
2014-01-01

Abstract

Whether IGF-1 has a protective or a detrimental role in vascular homeostasis remains unsettled. There is evidence that the C/T polymorphism rs35767 near the promoter region of the IGF1 gene located in chromosome 12 is associated with plasma IGF-1 levels. We investigated the effects of this polymorphism on circulating IGF-1 levels, carotid intima media thickness (cIMT) and endothelial-dependent vasodilation.
gen-2014
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/09 - MEDICINA INTERNA
English
Atherosclerosis; single nucleotide polymorphism; forearm blood flow; FBF; endothelial-dependent vasodilation; SNP; Endothelial dysfunction; EDV; cIMT; Carotid intima media thickness; carotid intima media thickness; IGF-1
Sesti, G., Mannino, G., Andreozzi, F., Greco, A., Perticone, M., Sciacqua, A., et al. (2014). A polymorphism at IGF1 locus is associated with carotid intima media thickness and endothelium-dependent vasodilatation. ATHEROSCLEROSIS, 232(1), 25-30 [10.1016/j.atherosclerosis.2013.10.024].
Sesti, G; Mannino, G; Andreozzi, F; Greco, A; Perticone, M; Sciacqua, A; Marini, Ma; Perticone, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/89848
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