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EnglishThe evolutionary and demographic history of the circular recombinant form CRF02 AG in a selected retrospective group of HIV-1 infected men who have sex with men (MSM) resident in Central Italy was investigated. Methods. A total of 55 HIV-1 subtype CRF02 AG pol sequences were analyzed using Bayesian methods and a relaxed molecular clock to reconstruct their dated phylogeny and estimate population dynamics. Results. Dated phylogeny indicated that the HIV-1 CRF02 AG strains currently circulating in Central Italy originated in the early 90’s. Bayesian phylogenetic analysis revealed the existence of a main HIV-1 CRF02 AG clade, introduced in the area of Rome before 2000 and subsequently differentiated in two different subclades with a different date of introduction (2000 versus 2005). All the sequences within clusters were interspersed, indicating that the MSM analyzed form a close and restricted network where the individuals, also moving within different clinical centers, attend the same places to meet and exchange sex. Conclusions. It was suggested that the HIV-1 CRF02 AG epidemic entered central Italy in the early 1990s, with a similar trend observed in western Europe
Giuliani, M., Santoro, M., Lo Presti, A., Cella, E., Scognamiglio, P., Lai, A., et al. (2013). Circulation of HIV-1 CRF02_AG among MSM population in central Italy: a molecular epidemiology-based study. BIOMED RESEARCH INTERNATIONAL, 2013, 810617-810617.
| Tipologia: | Articolo su rivista |
| Citazione: | Giuliani, M., Santoro, M., Lo Presti, A., Cella, E., Scognamiglio, P., Lai, A., et al. (2013). Circulation of HIV-1 CRF02_AG among MSM population in central Italy: a molecular epidemiology-based study. BIOMED RESEARCH INTERNATIONAL, 2013, 810617-810617. |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore MED/07 - Microbiologia e Microbiologia Clinica |
| Revisione (peer review): | Sì, ma tipo non specificato |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1155/2013/810617 |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | 2013 |
| Titolo: | Circulation of HIV-1 CRF02_AG among MSM population in central Italy: a molecular epidemiology-based study |
| Autori: | |
| Autori: | Giuliani, M; Santoro, M; Lo Presti, A; Cella, E; Scognamiglio, P; Lai, A; Latini, A; Fabeni, L; Gori, C; Pinnetti, C; Girardi, E; Perno, C; Zehender, G; Ciccozzi, M |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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