The evolutionary and demographic history of the circular recombinant form CRF02 AG in a selected retrospective group of HIV-1 infected men who have sex with men (MSM) resident in Central Italy was investigated. Methods. A total of 55 HIV-1 subtype CRF02 AG pol sequences were analyzed using Bayesian methods and a relaxed molecular clock to reconstruct their dated phylogeny and estimate population dynamics. Results. Dated phylogeny indicated that the HIV-1 CRF02 AG strains currently circulating in Central Italy originated in the early 90’s. Bayesian phylogenetic analysis revealed the existence of a main HIV-1 CRF02 AG clade, introduced in the area of Rome before 2000 and subsequently differentiated in two different subclades with a different date of introduction (2000 versus 2005). All the sequences within clusters were interspersed, indicating that the MSM analyzed form a close and restricted network where the individuals, also moving within different clinical centers, attend the same places to meet and exchange sex. Conclusions. It was suggested that the HIV-1 CRF02 AG epidemic entered central Italy in the early 1990s, with a similar trend observed in western Europe

Giuliani, M., Santoro, M., Lo Presti, A., Cella, E., Scognamiglio, P., Lai, A., et al. (2013). Circulation of HIV-1 CRF02_AG among MSM population in central Italy: a molecular epidemiology-based study. BIOMED RESEARCH INTERNATIONAL, 2013, 810617-810617 [10.1155/2013/810617].

Circulation of HIV-1 CRF02_AG among MSM population in central Italy: a molecular epidemiology-based study

SANTORO, MARIA;PERNO, CARLO FEDERICO;
2013-01-01

Abstract

The evolutionary and demographic history of the circular recombinant form CRF02 AG in a selected retrospective group of HIV-1 infected men who have sex with men (MSM) resident in Central Italy was investigated. Methods. A total of 55 HIV-1 subtype CRF02 AG pol sequences were analyzed using Bayesian methods and a relaxed molecular clock to reconstruct their dated phylogeny and estimate population dynamics. Results. Dated phylogeny indicated that the HIV-1 CRF02 AG strains currently circulating in Central Italy originated in the early 90’s. Bayesian phylogenetic analysis revealed the existence of a main HIV-1 CRF02 AG clade, introduced in the area of Rome before 2000 and subsequently differentiated in two different subclades with a different date of introduction (2000 versus 2005). All the sequences within clusters were interspersed, indicating that the MSM analyzed form a close and restricted network where the individuals, also moving within different clinical centers, attend the same places to meet and exchange sex. Conclusions. It was suggested that the HIV-1 CRF02 AG epidemic entered central Italy in the early 1990s, with a similar trend observed in western Europe
2013
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Homosexuality, Male; Phylogeny; HIV Infections; Molecular Epidemiology; Humans; Retrospective Studies; Bayes Theorem; HIV-1; Male; Italy; Female; Sex
Giuliani, M., Santoro, M., Lo Presti, A., Cella, E., Scognamiglio, P., Lai, A., et al. (2013). Circulation of HIV-1 CRF02_AG among MSM population in central Italy: a molecular epidemiology-based study. BIOMED RESEARCH INTERNATIONAL, 2013, 810617-810617 [10.1155/2013/810617].
Giuliani, M; Santoro, M; Lo Presti, A; Cella, E; Scognamiglio, P; Lai, A; Latini, A; Fabeni, L; Gori, C; Pinnetti, C; Girardi, E; Perno, Cf; Zehender,...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/89713
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