The formation of the NLRP3 inflammasome in the heart during acute myocardial infarction amplifies the inflammatory response and mediates further damage. Glyburide has NLRP3 inhibitory activity in vitro but requires very high doses in vivo, associated with hypoglycemia. The aim of this study was to measure the effects on the NLRP3 inflammasome of 16673-34-0, an intermediate substrate free of the cyclohexylurea moiety, involved in insulin release.
Marchetti, C., Chojnacki, J., Toldo, S., Mezzaroma, E., Tranchida, N., Rose, S., et al. (2014). A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 63(4), 316-322.
Tipologia: | Articolo su rivista |
Citazione: | Marchetti, C., Chojnacki, J., Toldo, S., Mezzaroma, E., Tranchida, N., Rose, S., et al. (2014). A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 63(4), 316-322. |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore MED/49 - Scienze Tecniche Dietetiche Applicate |
Revisione (peer review): | Esperti anonimi |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1097/FJC.0000000000000053 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | apr-2014 |
Titolo: | A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse |
Autori: | |
Autori: | Marchetti, C; Chojnacki, J; Toldo, S; Mezzaroma, E; Tranchida, N; Rose, S; Federici, M; Van Tassell, B; Zhang, S; Abbate, A |
Appare nelle tipologie: | 01 - Articolo su rivista |