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Tissue inhibitor of metalloproteinase 3 (TIMP3) is a stromal protein that inhibits the activity of various proteases and receptors. We have previously shown TIMP3 to be downregulated in metabolic and inflammatory disorders, such as type 2 diabetes mellitus. We have now generated an ApoE(-/-)Timp3(-/-) mouse model in which, through the use of genetics, metabolomics and in-vivo phenotypical analysis we investigated the role of TIMP3 in the development of atherosclerosis.

Tissue inhibitor of metalloproteinase 3 (TIMP3) is a stromal protein that inhibits the activity of various proteases and receptors. We have previously shown TIMP3 to be downregulated in metabolic and inflammatory disorders, such as type 2 diabetes mellitus. We have now generated an ApoE(-/-)Timp3(-/-) mouse model in which, through the use of genetics, metabolomics and in-vivo phenotypical analysis we investigated the role of TIMP3 in the development of atherosclerosis.

Stöhr, R., Cavalera, M., Menini, S., Mavilio, M., Casagrande, V., Rossi, C., et al. (2014). Loss of TIMP3 exacerbates atherosclerosis in ApoE null mice. ATHEROSCLEROSIS, 235(2), 438-443 [10.1016/j.atherosclerosis.2014.05.946].

Loss of TIMP3 exacerbates atherosclerosis in ApoE null mice

CAVALERA, MICHELE;URBANI, ANDREA;CARDELLINI, MARINA;MENGHINI, ROSSELLA;FEDERICI, MASSIMO
2014-01-01

Abstract

Tissue inhibitor of metalloproteinase 3 (TIMP3) is a stromal protein that inhibits the activity of various proteases and receptors. We have previously shown TIMP3 to be downregulated in metabolic and inflammatory disorders, such as type 2 diabetes mellitus. We have now generated an ApoE(-/-)Timp3(-/-) mouse model in which, through the use of genetics, metabolomics and in-vivo phenotypical analysis we investigated the role of TIMP3 in the development of atherosclerosis.
2014
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE
Settore BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA
English
Con Impact Factor ISI
Tissue inhibitor of metalloproteinase 3 (TIMP3) is a stromal protein that inhibits the activity of various proteases and receptors. We have previously shown TIMP3 to be downregulated in metabolic and inflammatory disorders, such as type 2 diabetes mellitus. We have now generated an ApoE(-/-)Timp3(-/-) mouse model in which, through the use of genetics, metabolomics and in-vivo phenotypical analysis we investigated the role of TIMP3 in the development of atherosclerosis.
Atherosclerosis; Inflammation; Metabolism; Metabolomics; TIMP3; Animals; Apolipoproteins E; Atherosclerosis; Macrophages; Male; Metabolomics; Mice, Knockout; Plaque, Atherosclerotic; Tissue Inhibitor of Metalloproteinase-3
Atherosclerosis; TIMP3; Metabolomics; Metabolism; Inflammation
Stöhr, R., Cavalera, M., Menini, S., Mavilio, M., Casagrande, V., Rossi, C., et al. (2014). Loss of TIMP3 exacerbates atherosclerosis in ApoE null mice. ATHEROSCLEROSIS, 235(2), 438-443 [10.1016/j.atherosclerosis.2014.05.946].
Stöhr, R; Cavalera, M; Menini, S; Mavilio, M; Casagrande, V; Rossi, C; Urbani, A; Cardellini, M; Pugliese, G; Menghini, R; Federici, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/89591
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