Acute myocardial infarction (AMI), is related to a diffuse active inflammation of the coronary tree associated with rupture of one of the multiple vulnerable plaques. The presence of soluble mediators of inflammation with their synergic or antagonistic actions coordinates the physiological response determining the plaque fate and the fatal event. The present study focus on the cytokines network operating in human coronary plaques of patients died from AMI and controls, pointing out that coronaries of AMI patients produce PTX3 protein twice as that of controls and express high level of PTX3 mRNA.
Pucci, S., Fisco, T., Zonetti, M., Bonanno, E., Mazzarelli, P., Mauriello, A. (2014). PTX3: A modulator of human coronary plaque vulnerability acting by macrophages type 2. INTERNATIONAL JOURNAL OF CARDIOLOGY, 176(3), 710-717 [10.1016/j.ijcard.2014.07.109].
PTX3: A modulator of human coronary plaque vulnerability acting by macrophages type 2
PUCCI, SABINA;BONANNO, ELENA;MAZZARELLI, PAOLA;MAURIELLO, ALESSANDRO
2014-10-20
Abstract
Acute myocardial infarction (AMI), is related to a diffuse active inflammation of the coronary tree associated with rupture of one of the multiple vulnerable plaques. The presence of soluble mediators of inflammation with their synergic or antagonistic actions coordinates the physiological response determining the plaque fate and the fatal event. The present study focus on the cytokines network operating in human coronary plaques of patients died from AMI and controls, pointing out that coronaries of AMI patients produce PTX3 protein twice as that of controls and express high level of PTX3 mRNA.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
