1. The dopamine (DA) D1-receptor family is highly represented in the mammalian brain and particularly in the nigrostriatal system, whose integrity is crucial for the execution of motor performances. 2. In the last decade, our understanding of the electrophysiology of D1 receptors on caudate-putamen neurons has greatly improved. The effects of the activation of striatal D1 receptors were studied by extracellular single unit recordings in the intact animal as well as by intracellular recordings in rat brain slice preparation. More recently, whole-cell recordings on isolated striatal neurons have further addressed this issue and confirmed the inhibitory modulatory role of D1 receptor on the electrical activity of striatal neurons. 3. Several important questions, however, concerning the functional effects of D1 receptor activation in the basal ganglia are still debated: the cellular segregation of the distribution of D1-D2-like receptors, their synergistic or opposite functional roles at the second messenger level, the effects of D1 receptor activation on the transmitter release and the modifications of D1 receptor pharmacology in dopamine-denervated striata. 4. A different perspective will also be discussed: the involvement of D1 receptors in long-term changes of synaptic efficacy in the striatum as a possible correlate of motor learning.

Stefani, A., De Murtas, M., Pisani, A., Stratta, F., Bonci, A., Mercuri, N., et al. (1995). Electrophysiology of dopamine D-1 receptors in the basal ganglia: old facts and new perspectives. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 19(5), 779-793.

Electrophysiology of dopamine D-1 receptors in the basal ganglia: old facts and new perspectives

STEFANI, ALESSANDRO;PISANI, ANTONIO;MERCURI, NICOLA BIAGIO;CALABRESI, PAOLO
1995-09

Abstract

1. The dopamine (DA) D1-receptor family is highly represented in the mammalian brain and particularly in the nigrostriatal system, whose integrity is crucial for the execution of motor performances. 2. In the last decade, our understanding of the electrophysiology of D1 receptors on caudate-putamen neurons has greatly improved. The effects of the activation of striatal D1 receptors were studied by extracellular single unit recordings in the intact animal as well as by intracellular recordings in rat brain slice preparation. More recently, whole-cell recordings on isolated striatal neurons have further addressed this issue and confirmed the inhibitory modulatory role of D1 receptor on the electrical activity of striatal neurons. 3. Several important questions, however, concerning the functional effects of D1 receptor activation in the basal ganglia are still debated: the cellular segregation of the distribution of D1-D2-like receptors, their synergistic or opposite functional roles at the second messenger level, the effects of D1 receptor activation on the transmitter release and the modifications of D1 receptor pharmacology in dopamine-denervated striata. 4. A different perspective will also be discussed: the involvement of D1 receptors in long-term changes of synaptic efficacy in the striatum as a possible correlate of motor learning.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - Neurologia
English
Con Impact Factor ISI
Animals; Sulpiride; Patch-Clamp Techniques; Receptors, Dopamine D1; Dopamine Antagonists; Electrophysiology; Basal Ganglia
Stefani, A., De Murtas, M., Pisani, A., Stratta, F., Bonci, A., Mercuri, N., et al. (1995). Electrophysiology of dopamine D-1 receptors in the basal ganglia: old facts and new perspectives. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 19(5), 779-793.
Stefani, A; De Murtas, M; Pisani, A; Stratta, F; Bonci, A; Mercuri, Nb; Calabresi, P
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/88322
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