Simultaneous measurements of membrane potential and intracellular Ca2+ were used to study the effects of hypoxia on striatal and cortical neurones. Striatal neurones responded to hypoxia with a reversible membrane depolarization coupled with a transient increase in intracellular Ca2+. Thirty minutes of hypoxia caused an irreversible membrane depolarization associated with a massive raise in Ca2+ levels, leading to cell death. Conversely, cortical neurones were more resistant to O2 deprivation. Hypoxia (4-10 min) induced minimal changes in both membrane potential and Ca2+ signals. Longer periods (20-30 min) caused an initial membrane hyperpolarization followed by a large but reversible depolarization coupled with a transient increase in Ca2+ signals. These results support the hypothesis of a differential sensitivity of central neurones to hypoxia, suggesting that striatal neurones are more vulnerable than cortical cells.

Pisani, A., Calabresi, P., Bernardi, G. (1997). Hypoxia in striatal and cortical neurones: membrane potential and Ca2+ measurements. NEUROREPORT, 8(5), 1143-1147.

Hypoxia in striatal and cortical neurones: membrane potential and Ca2+ measurements

PISANI, ANTONIO;CALABRESI, PAOLO;BERNARDI, GIORGIO
1997-03-24

Abstract

Simultaneous measurements of membrane potential and intracellular Ca2+ were used to study the effects of hypoxia on striatal and cortical neurones. Striatal neurones responded to hypoxia with a reversible membrane depolarization coupled with a transient increase in intracellular Ca2+. Thirty minutes of hypoxia caused an irreversible membrane depolarization associated with a massive raise in Ca2+ levels, leading to cell death. Conversely, cortical neurones were more resistant to O2 deprivation. Hypoxia (4-10 min) induced minimal changes in both membrane potential and Ca2+ signals. Longer periods (20-30 min) caused an initial membrane hyperpolarization followed by a large but reversible depolarization coupled with a transient increase in Ca2+ signals. These results support the hypothesis of a differential sensitivity of central neurones to hypoxia, suggesting that striatal neurones are more vulnerable than cortical cells.
24-mar-1997
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - NEUROLOGIA
English
Con Impact Factor ISI
Rats; Cerebral Cortex; Calcium Channels; Animals; Neurons; Hypoxia, Brain; Rats, Wistar; Corpus Striatum; Membrane Potentials; Male
Pisani, A., Calabresi, P., Bernardi, G. (1997). Hypoxia in striatal and cortical neurones: membrane potential and Ca2+ measurements. NEUROREPORT, 8(5), 1143-1147.
Pisani, A; Calabresi, P; Bernardi, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/88313
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