Experimental evidence supports a major role of increased intracellular calcium [Ca2+]i levels in the induction of neuronal damage during cerebral ischemia. However, the source of Ca2+ rise has not been fully elucidated. To clarify further the role and the origin of Ca2+ in cerebral ischemia, we have studied the effects of various pharmacological agents in an in vitro model of oxygen (O2)/glucose deprivation.

Pisani, A., Calabresi, P., Tozzi, A., D'Angelo, V., Bernardi, G. (1998). L-type Ca2+ channel blockers attenuate electrical changes and Ca2+ rise induced by oxygen/glucose deprivation in cortical neurons. STROKE, 29(1), 196-196-201; discussion 202.

L-type Ca2+ channel blockers attenuate electrical changes and Ca2+ rise induced by oxygen/glucose deprivation in cortical neurons

PISANI, ANTONIO;CALABRESI, PAOLO;D'Angelo, V;BERNARDI, GIORGIO
1998-01-01

Abstract

Experimental evidence supports a major role of increased intracellular calcium [Ca2+]i levels in the induction of neuronal damage during cerebral ischemia. However, the source of Ca2+ rise has not been fully elucidated. To clarify further the role and the origin of Ca2+ in cerebral ischemia, we have studied the effects of various pharmacological agents in an in vitro model of oxygen (O2)/glucose deprivation.
gen-1998
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - NEUROLOGIA
English
Con Impact Factor ISI
Animals; Pyramidal Cells; Calcium; Dantrolene; Glucose; Calcium Channel Blockers; Cytophotometry; Tetrodotoxin; Fluorescent Dyes; Energy Metabolism; Nifedipine; Rats; Calcium Channels; Oxygen Consumption; Rats, Wistar; Cell Membrane; Nimodipine; Membrane Potentials; Brain Ischemia; Fura-2; Time Factors; Male; Excitatory Amino Acid Antagonists
Pisani, A., Calabresi, P., Tozzi, A., D'Angelo, V., Bernardi, G. (1998). L-type Ca2+ channel blockers attenuate electrical changes and Ca2+ rise induced by oxygen/glucose deprivation in cortical neurons. STROKE, 29(1), 196-196-201; discussion 202.
Pisani, A; Calabresi, P; Tozzi, A; D'Angelo, V; Bernardi, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/88312
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