Alterations in neuronal calcium (Ca2+) homeostasis are believed to play an essential role in the generation and propagation of epileptiform events. Levetiracetam (LEV) and lamotrigine (LTG), novel antiepileptic drugs (AEDs), were tested on epileptiform events and the corresponding elevations in intracellular Ca2+ concentration ([Ca2+]i) recorded from rat neocortical slices.
Pisani, A., Bonsi, P., Martella, G., De Persis, C., Costa, C., Pisani, F., et al. (2004). Intracellular calcium increase in epileptiform activity: modulation by levetiracetam and lamotrigine. EPILEPSIA, 45(7), 719-728 [10.1111/j.0013-9580.2004.02204.x].
Intracellular calcium increase in epileptiform activity: modulation by levetiracetam and lamotrigine
PISANI, ANTONIO;MARTELLA, GIUSEPPINA;BERNARDI, GIORGIO;CALABRESI, PAOLO
2004-07-01
Abstract
Alterations in neuronal calcium (Ca2+) homeostasis are believed to play an essential role in the generation and propagation of epileptiform events. Levetiracetam (LEV) and lamotrigine (LTG), novel antiepileptic drugs (AEDs), were tested on epileptiform events and the corresponding elevations in intracellular Ca2+ concentration ([Ca2+]i) recorded from rat neocortical slices.| File | Dimensione | Formato | |
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