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We analyzed the effects of seletracetam (ucb 44212; SEL), a new antiepileptic drug candidate, in an in vitro model of epileptic activity. The activity of SEL was compared to the effects of levetiracetam (LEV; Keppra), in the same assays.

Martella, G., Bonsi, P., Sciamanna, G., Platania, P., Madeo, G., Tassone, A., et al. (2009). Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro. EPILEPSIA, 50(4), 702-710 [10.1111/j.1528-1167.2008.01915.x].

Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro

MARTELLA, GIUSEPPINA;SCIAMANNA, GIUSEPPE;MADEO, GRAZIELLA;PISANI, ANTONIO
2009-04-01

Abstract

We analyzed the effects of seletracetam (ucb 44212; SEL), a new antiepileptic drug candidate, in an in vitro model of epileptic activity. The activity of SEL was compared to the effects of levetiracetam (LEV; Keppra), in the same assays.
apr-2009
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - NEUROLOGIA
English
Con Impact Factor ISI
Animals; Calcium; Dose-Response Relationship, Drug; Pyrrolidinones; Bicuculline; Calcium Channel Blockers; Neural Inhibition; Biophysics; Rats; Calcium Channels; GABA Antagonists; Patch-Clamp Techniques; Neurons; Rats, Wistar; Potassium Channel Blockers; Piracetam; Membrane Potentials; 4-Aminopyridine; Magnesium; Neocortex; Anticonvulsants; Male
Martella, G., Bonsi, P., Sciamanna, G., Platania, P., Madeo, G., Tassone, A., et al. (2009). Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro. EPILEPSIA, 50(4), 702-710 [10.1111/j.1528-1167.2008.01915.x].
Martella, G; Bonsi, P; Sciamanna, G; Platania, P; Madeo, G; Tassone, A; Cuomo, D; Pisani, A
Articolo su rivista
01 - Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/88281
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