A new stereoselective synthesis of 2′-C-methyluridine was carried out. The preparation of the corresponding protected phosphoramidite suitable for the automated synthesis of oligonucleotides, including the regioselective protection of the 2′-hydroxyl group, is described here. This new modified nucleotide is expected to generate RNA analogues potentially useful in applications where proper RNA folding is required since the 2′-hydroxyl is conserved.

Gallo, M., Monteagudo, E., Cicero, D.o., Torres, H., Iribarren, A. (2001). 2´-C-Methyluridine phosphoramidite: a new building block for the preparation of RNA analogues carrying the 2´-hydroxyl group. TETRAHEDRON, 57, 5707-5713 [10.1016/S0040-4020(01)00484-7].

2´-C-Methyluridine phosphoramidite: a new building block for the preparation of RNA analogues carrying the 2´-hydroxyl group

CICERO, DANIEL OSCAR;
2001

Abstract

A new stereoselective synthesis of 2′-C-methyluridine was carried out. The preparation of the corresponding protected phosphoramidite suitable for the automated synthesis of oligonucleotides, including the regioselective protection of the 2′-hydroxyl group, is described here. This new modified nucleotide is expected to generate RNA analogues potentially useful in applications where proper RNA folding is required since the 2′-hydroxyl is conserved.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/10
English
Gallo, M., Monteagudo, E., Cicero, D.o., Torres, H., Iribarren, A. (2001). 2´-C-Methyluridine phosphoramidite: a new building block for the preparation of RNA analogues carrying the 2´-hydroxyl group. TETRAHEDRON, 57, 5707-5713 [10.1016/S0040-4020(01)00484-7].
Gallo, M; Monteagudo, E; Cicero, Do; Torres, H; Iribarren, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/87876
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