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EnglishProtein-protein interactions play an essential role in the regulation of most cellular processes. The process of viral infection is no exception and many viral pathogenic strategies involve targeting and perturbing host-protein interactions. The characterization of the host protein subnetworks disturbed by invading viruses is a major goal of viral research and may contribute to reveal fundamental biological mechanisms and to identify new therapeutic strategies. To assist in this approach, we have developed a database, VirusMINT, which stores in a structured format most of the published interactions between viral and host proteome. Although SH3 are the most ubiquitous and abundant class of protein binding modules, VirusMINT contains only a few interactions mediated by this domain class. To overcome this limitation, we have applied the whole interactome scanning experiment approach to identify interactions between 15 human SH3 domains and viral proline-rich peptides of two oncogenic viruses, human papillomavirus type 16 and human adenovirus A type 12. This approach identifies 114 new potential interactions between the human SH3 domains and proline-rich regions of the two viral proteomes.
Carducci, M., Licata, L., Peluso, D., Castagnoli, L., & Cesareni, G. (2010). Enriching the viral-host interactomes with interactions mediated by SH3 domains. AMINO ACIDS, 38(5), 1541-7.
| Tipologia: | Articolo su rivista |
| Citazione: | Carducci, M., Licata, L., Peluso, D., Castagnoli, L., & Cesareni, G. (2010). Enriching the viral-host interactomes with interactions mediated by SH3 domains. AMINO ACIDS, 38(5), 1541-7. |
| IF: | Con Impact Factor ISI |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore BIO/18 - Genetica |
| Revisione (peer review): | Sì, ma tipo non specificato |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s00726-009-0375-z |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | mag-2010 |
| Titolo: | Enriching the viral-host interactomes with interactions mediated by SH3 domains |
| Autori: | |
| Autori: | Carducci, M; Licata, L; Peluso, D; Castagnoli, L; Cesareni, G |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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