Common biological features between cancer and atherosclerosis suggest possible association of p53 with atherosclerotic diseases, but data on such a relationship are controversial, suggesting interactions with other variables. Acid phosphatase locus 1 (ACPACP₁) is a polymorphic gene that controls the synthesis of an enzyme involved in important metabolic functions. Since ACPACP₁ is associated with coronary artery disease (CAD), we searched for possible interactions between this enzyme and p53 codon 72 polymorphism with regard to their effects on susceptibility to CAD.
Gloria Bottini, F., Banci, M., Saccucci, P., Neri, A., Bottini, E., Magrini, A. (2012). p53 codon 72 polymorphism and coronary artery disease: evidence of interaction with ACP₁. MEDICAL SCIENCE MONITOR, 18(12), CR712-CR712-5.
p53 codon 72 polymorphism and coronary artery disease: evidence of interaction with ACP₁
SACCUCCI, PATRIZIA;NERI, ANNA;BOTTINI, EGIDIO;MAGRINI, ANDREA
2012-12-01
Abstract
Common biological features between cancer and atherosclerosis suggest possible association of p53 with atherosclerotic diseases, but data on such a relationship are controversial, suggesting interactions with other variables. Acid phosphatase locus 1 (ACPACP₁) is a polymorphic gene that controls the synthesis of an enzyme involved in important metabolic functions. Since ACPACP₁ is associated with coronary artery disease (CAD), we searched for possible interactions between this enzyme and p53 codon 72 polymorphism with regard to their effects on susceptibility to CAD.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
