Glutaredoxin 1 (Grx1), a small protein belonging to the thioredoxin family, is involved in redox-regulation since it catalyzes the reduction of protein disulfides and that of mixed disulfides. It was reported to modulate active copper extrusion from cells, by affecting the function of the pumps ATP7A and B. These are components of the network of protein chaperones involved in the control of the homeostasis of copper, an essential, though harmful, metal. However, the effect of Grx1 on copper levels, copper chaperones and copper-elicited cell toxicity was never investigated.

De Benedetto, M., Capo, C.r., Ferri, A., Valle, C., Polimanti, R., Carri', M.t., et al. (2014). Glutaredoxin 1 is a major player in copper metabolism in neuroblastoma cells. BIOCHIMICA ET BIOPHYSICA ACTA, 1840(1), 255-261 [10.1016/j.bbagen.2013.09.008].

Glutaredoxin 1 is a major player in copper metabolism in neuroblastoma cells

CAPO, CONCETTA ROSA;CARRI', MARIA TERESA;ROSSI, LUISA
2014-01-01

Abstract

Glutaredoxin 1 (Grx1), a small protein belonging to the thioredoxin family, is involved in redox-regulation since it catalyzes the reduction of protein disulfides and that of mixed disulfides. It was reported to modulate active copper extrusion from cells, by affecting the function of the pumps ATP7A and B. These are components of the network of protein chaperones involved in the control of the homeostasis of copper, an essential, though harmful, metal. However, the effect of Grx1 on copper levels, copper chaperones and copper-elicited cell toxicity was never investigated.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/10
English
Con Impact Factor ISI
Real-Time Polymerase Chain Reaction; Superoxide Dismutase; Apoptosis; Glutathione; Humans; SH-SY5Y; Mitochondria; Glutaredoxins; Copper; Reverse Transcriptase Polymerase Chain Reaction; Cation Transport Proteins; Cell Proliferation; Neuroblastoma; RNA, Messenger; Oxidation-Reduction; Chromatography, Affinity; Grx1; Blotting, Western; Tumor Cells, Cultured; Ctr1
De Benedetto, M., Capo, C.r., Ferri, A., Valle, C., Polimanti, R., Carri', M.t., et al. (2014). Glutaredoxin 1 is a major player in copper metabolism in neuroblastoma cells. BIOCHIMICA ET BIOPHYSICA ACTA, 1840(1), 255-261 [10.1016/j.bbagen.2013.09.008].
De Benedetto, M; Capo, Cr; Ferri, A; Valle, C; Polimanti, R; Carri', Mt; Rossi, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/85391
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