Fabrication of multifunctional ultrasound contrast agents (UCAs) has been recently addressed by several research groups. A versatile strategy for the synthesis of UCA precursors in the form of biodegradable vesicles with a biocompatible crosslinked polymer shell is described. Upon ultrasound irradiation, acoustic droplet vaporization transforms such particles into microbubbles behaving as UCAs. This proof of concept entails the features of a potential theranostic microdevice.
Capece, S., Chiessi, E., Cavalli, R., Giustetto, P., Grishenkov, D., Paradossi, G. (2013). A general strategy for obtaining biodegradable polymer shelled microbubbles as theranostic devices. CHEMICAL COMMUNICATIONS, 49(51), 5763-5765 [10.1039/c3cc42037j].
A general strategy for obtaining biodegradable polymer shelled microbubbles as theranostic devices
CHIESSI, ESTER;PARADOSSI, GAIO
2013-01-01
Abstract
Fabrication of multifunctional ultrasound contrast agents (UCAs) has been recently addressed by several research groups. A versatile strategy for the synthesis of UCA precursors in the form of biodegradable vesicles with a biocompatible crosslinked polymer shell is described. Upon ultrasound irradiation, acoustic droplet vaporization transforms such particles into microbubbles behaving as UCAs. This proof of concept entails the features of a potential theranostic microdevice.| File | Dimensione | Formato | |
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