The unique performance of a partially hydrophobic derivative of hyaluronic acid, HYADD4, bearing 2–3 hexadecylic side chains every 100 repeating units, enables hydrogels based on this polymer to be suitably used as a viscosupplement to replace synovial fluid in stressed or injured articular joints. This contribution addresses: i) as to whether there is a self-assembly process driving the HYADD4 hydrogel stabilization and ii) what the characteristics of the long-range dynamics governing the macroscopic viscoelastic behavior are, and to what extent these features are different from those present in the parent polymer (i.e., hyaluronic acid). Mesoscale dynamic and static properties are interpreted in the light of “sticky reptation theory” and evaluated in combination with small-angle neutron scattering results.

Finelli, I., Chiessi, E., Oddo, L., Galesso, D., Renier, D., & Paradossi, G. (2014). Collective Dynamics and Transient Behavior of Partially Hydrophobic Hyaluronic Acid Chains. MACROMOLECULAR CHEMISTRY AND PHYSICS, 2, 140-147 [10.1002/macp.201300503].

Collective Dynamics and Transient Behavior of Partially Hydrophobic Hyaluronic Acid Chains

CHIESSI, ESTER;ODDO, LETIZIA;PARADOSSI, GAIO
2014

Abstract

The unique performance of a partially hydrophobic derivative of hyaluronic acid, HYADD4, bearing 2–3 hexadecylic side chains every 100 repeating units, enables hydrogels based on this polymer to be suitably used as a viscosupplement to replace synovial fluid in stressed or injured articular joints. This contribution addresses: i) as to whether there is a self-assembly process driving the HYADD4 hydrogel stabilization and ii) what the characteristics of the long-range dynamics governing the macroscopic viscoelastic behavior are, and to what extent these features are different from those present in the parent polymer (i.e., hyaluronic acid). Mesoscale dynamic and static properties are interpreted in the light of “sticky reptation theory” and evaluated in combination with small-angle neutron scattering results.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore CHIM/02 - Chimica Fisica
English
hyaluronic acid;hydrogels;rheology;self-assembly;viscosupplements
Finelli, I., Chiessi, E., Oddo, L., Galesso, D., Renier, D., & Paradossi, G. (2014). Collective Dynamics and Transient Behavior of Partially Hydrophobic Hyaluronic Acid Chains. MACROMOLECULAR CHEMISTRY AND PHYSICS, 2, 140-147 [10.1002/macp.201300503].
Finelli, I; Chiessi, E; Oddo, L; Galesso, D; Renier, D; Paradossi, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/84871
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