Microbubbles (MBs) are commonly used as injectable ultrasound contrast agent (UCA) in modern ultrasonography. Polymer-shelled UCAs present additional potentialities with respect to marketed lipid-shelled UCAs. They are more robust; that is, they have longer shelf and circulation life, and surface modifications are quite easily accomplished to obtain enhanced targeting and local drug delivery. The next generation of UCAs will be required to support not only ultrasound-based imaging methods but also other complementary diagnostic approaches such as magnetic resonance imaging or computer tomography. This work addresses the features of MBs that could function as contrast agents for both ultrasound and magnetic resonance imaging. The results indicate that the introduction of iron oxide nanoparticles (SPIONs) in the poly(vinyl alcohol) shell or on the external surface of the MBs does not greatly decrease the echogenicity of the host MBs compared with the unmodified one. The presence of SPIONs provides enough magnetic susceptibility to the MBs to accomplish good detectability both in vitro and in vivo. The distribution of SPIONs on the shell and their aggregation state seem to be key factors for the optimization of the transverse relaxation rate.

Brismar, T., Grishenkov, D., Gustafsson, B., Harmark, J., Barrefelt, A., Kothapalli, S., et al. (2012). Magnetite Nanoparticles Can Be Coupled to Microbubbles to Support Multimodal Imaging. BIOMACROMOLECULES, 13(5), 1390-1399 [10.1021/bm300099f].

Magnetite Nanoparticles Can Be Coupled to Microbubbles to Support Multimodal Imaging

ODDO, LETIZIA;PARADOSSI, GAIO
2012

Abstract

Microbubbles (MBs) are commonly used as injectable ultrasound contrast agent (UCA) in modern ultrasonography. Polymer-shelled UCAs present additional potentialities with respect to marketed lipid-shelled UCAs. They are more robust; that is, they have longer shelf and circulation life, and surface modifications are quite easily accomplished to obtain enhanced targeting and local drug delivery. The next generation of UCAs will be required to support not only ultrasound-based imaging methods but also other complementary diagnostic approaches such as magnetic resonance imaging or computer tomography. This work addresses the features of MBs that could function as contrast agents for both ultrasound and magnetic resonance imaging. The results indicate that the introduction of iron oxide nanoparticles (SPIONs) in the poly(vinyl alcohol) shell or on the external surface of the MBs does not greatly decrease the echogenicity of the host MBs compared with the unmodified one. The presence of SPIONs provides enough magnetic susceptibility to the MBs to accomplish good detectability both in vitro and in vivo. The distribution of SPIONs on the shell and their aggregation state seem to be key factors for the optimization of the transverse relaxation rate.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore CHIM/02 - Chimica Fisica
English
Brismar, T., Grishenkov, D., Gustafsson, B., Harmark, J., Barrefelt, A., Kothapalli, S., et al. (2012). Magnetite Nanoparticles Can Be Coupled to Microbubbles to Support Multimodal Imaging. BIOMACROMOLECULES, 13(5), 1390-1399 [10.1021/bm300099f].
Brismar, T; Grishenkov, D; Gustafsson, B; Harmark, J; Barrefelt, A; Kothapalli, S; Margheritelli, S; Oddo, L; Caidhal, K; Hebert, H; Paradossi, G
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
bm300099f.pdf

non disponibili

Licenza: Non specificato
Dimensione 1.68 MB
Formato Adobe PDF
1.68 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/84768
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 69
  • ???jsp.display-item.citation.isi??? 66
social impact