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EnglishThe epidermal growth factor receptor (EGFR) is one member of the ErbB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands leads to autophosphorylation of tyrosine residues on the receptor and subsequent activation of signal transduction pathways that are involved in regulating cellular proliferation, differentiation, and survival. Ligand binding with EGFR results in receptor homo- or heterodimerization at the cell surface.
Castagnoli, L. (2008). Signaling by EGFR. Cold Spring Harbor Laboratory (CSHL), Ontario Institute for Cancer Research (OICR), European Bioinformatics Institute (EBI).
| Autori: | ||
| Autori: | Castagnoli, L | |
| Titolo: | Signaling by EGFR | |
| Data di pubblicazione: | 28-feb-2008 | |
| Settore Scientifico Disciplinare: | Settore BIO/18 - Genetica | |
| Lingua: | English | |
| Rilevanza: | Rilevanza internazionale | |
| Altre informazioni significative: | REACTOME is an open-source, open access, manually curated and peer-reviewed pathway database. Pathway annotations are authored by expert biologists, in collaboration with Reactome editorial staff and cross-referenced to many bioinformatics databases. These include NCBI Entrez Gene, Ensembl and UniProt databases, the UCSC and HapMap Genome Browsers, the KEGG Compound and ChEBI small molecule databases, PubMed, and Gene Ontology. | |
| URL: | http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=177929&ID=177929 | |
| Tipologia: | Monografia | |
| Citazione: | Castagnoli, L. (2008). Signaling by EGFR. Cold Spring Harbor Laboratory (CSHL), Ontario Institute for Cancer Research (OICR), European Bioinformatics Institute (EBI). | |
| Appare nelle tipologie: | 04 - Monografia |
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