Alterations of glutamate-mediated synaptic transmission occur in both multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), the animal model of MS. Here we investigated whether intracerebroventricular (Icv) administration of cladribine has effects on EAE. Icv infusion of cladribine reduced the clinical deficits of EAE mice and reversed EAE-induced enhancement of excitatory postsynaptic current (sEPSC) frequency, a neurophysiological measure of glutamatergic synaptopathy associated with central inflammation. Cladribine failed to interfere with EAE-induced microglial and astroglial activation, but blocked EAE synaptic alterations by interfering with interleukin-1β effects. Cladribine possesses neuroprotective properties in experimental MS that are independent of its peripheral immunosuppressant action.

Musella, A., Mandolesi, G., Gentile, A., Rossi, S., Studer, V., Motta, C., et al. (2013). Cladribine interferes with IL-1β synaptic effects in experimental multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY, 264(1-2), 8-13 [10.1016/j.jneuroim.2013.08.009].

Cladribine interferes with IL-1β synaptic effects in experimental multiple sclerosis

Gentile, A;Motta, C;CENTONZE, DIEGO
2013-11-15

Abstract

Alterations of glutamate-mediated synaptic transmission occur in both multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), the animal model of MS. Here we investigated whether intracerebroventricular (Icv) administration of cladribine has effects on EAE. Icv infusion of cladribine reduced the clinical deficits of EAE mice and reversed EAE-induced enhancement of excitatory postsynaptic current (sEPSC) frequency, a neurophysiological measure of glutamatergic synaptopathy associated with central inflammation. Cladribine failed to interfere with EAE-induced microglial and astroglial activation, but blocked EAE synaptic alterations by interfering with interleukin-1β effects. Cladribine possesses neuroprotective properties in experimental MS that are independent of its peripheral immunosuppressant action.
15-nov-2013
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - NEUROLOGIA
English
Con Impact Factor ISI
Musella, A., Mandolesi, G., Gentile, A., Rossi, S., Studer, V., Motta, C., et al. (2013). Cladribine interferes with IL-1β synaptic effects in experimental multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY, 264(1-2), 8-13 [10.1016/j.jneuroim.2013.08.009].
Musella, A; Mandolesi, G; Gentile, A; Rossi, S; Studer, V; Motta, C; Sepman, H; Fresegna, D; Haji, N; Paolillo, A; Matarese, G; Centonze, D
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/82750
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