Weight gain is a common problem reported by users of estroprogestins (EPs) and is a frequent reason for EP discontinuation, even if this problem is not confirmed in several clinical studies. We studied the impact of a EP containing ethinyl estradiol (EE) 20 mu g plus levonorgestrel (LNG) 100 mu g on body weight (BW) and body composition in 47 treated women and 31 women as controls. Also, we studied the effect of this association on metabolic parameters (glycemia, lipid profile). EE20/LNG100 had no significant impact on body weight, body composition (fat mass, fat-free mass, total body water, intracellular water, extracellular water) or metabolic profile in comparison with no treatment. Thus, the use of EE20/LNG100 showed no impact on metabolic parameters, body weight and body composition. This could be important not only for the safety profile of this combination, but also in increasing patient compliance.

Lello, S., Vittori, G., Paoletti, A., Sorge, R.p., Guardianelli, F., Melis, G. (2007). Effects on body weight and body composition of a low-dose oral estroprogestin containing ethinyl estradiol 20 mu g plus levonorgestrel 100 mu g. GYNECOLOGICAL ENDOCRINOLOGY, 23(11), 632-637 [10.1080/09513590701582539].

Effects on body weight and body composition of a low-dose oral estroprogestin containing ethinyl estradiol 20 mu g plus levonorgestrel 100 mu g

SORGE, ROBERTO PIETRO;
2007-01-01

Abstract

Weight gain is a common problem reported by users of estroprogestins (EPs) and is a frequent reason for EP discontinuation, even if this problem is not confirmed in several clinical studies. We studied the impact of a EP containing ethinyl estradiol (EE) 20 mu g plus levonorgestrel (LNG) 100 mu g on body weight (BW) and body composition in 47 treated women and 31 women as controls. Also, we studied the effect of this association on metabolic parameters (glycemia, lipid profile). EE20/LNG100 had no significant impact on body weight, body composition (fat mass, fat-free mass, total body water, intracellular water, extracellular water) or metabolic profile in comparison with no treatment. Thus, the use of EE20/LNG100 showed no impact on metabolic parameters, body weight and body composition. This could be important not only for the safety profile of this combination, but also in increasing patient compliance.
2007
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/13 - ENDOCRINOLOGIA
English
Con Impact Factor ISI
bioelectrical impedance analysis; body composition; body weight; ethinyl estradiol; evonorgestrelalanine aminotransferase; aspartate aminotransferase; cholesterol; creatinine; ethinylestradiol; high density lipoprotein cholesterol;
Lello, S., Vittori, G., Paoletti, A., Sorge, R.p., Guardianelli, F., Melis, G. (2007). Effects on body weight and body composition of a low-dose oral estroprogestin containing ethinyl estradiol 20 mu g plus levonorgestrel 100 mu g. GYNECOLOGICAL ENDOCRINOLOGY, 23(11), 632-637 [10.1080/09513590701582539].
Lello, S; Vittori, G; Paoletti, A; Sorge, Rp; Guardianelli, F; Melis, G
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/8123
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