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EnglishThe synthetic triterpenoid CDDO-Im-induced apoptosis of patient-derived AML blasts: 11/25 AMLs were highly sensitive, while the remaining were moderately sensitive to CDDO-Im. The addition of TRAIL significantly potentiated the cytotoxic effect of CDDO-Im, through mechanisms involving the induction of TRAIL-R1/TRAIL-R2 and downmodulation of TRAIL-R3/TRAIL-R4. Biochemical studies showed that CDDO-Im: induced a rapid and marked GSH depletion and antioxidants (GSH or NAC) completely inhibited its pro-apoptotic effect; sequentially activated caspase-8, -9 and -3; caspase inhibitors partially protected AML blasts from CDDO-Im-induced apoptosis; resistance of AML blasts to CDDO-Im-induced apoptosis correlated with low caspase-8/FADD and high Bcl-X-L expression in leukemic blasts.
Riccioni, R., Senese, M., Diverio, D., Riti, V., Mariani, G., Boe, A., et al. (2008). Resistance of acute myeloid leukemic cells to the triterpenoid CDDO-Imidazolide is associated with low caspase-8 and FADD levels. LEUKEMIA RESEARCH, 32(8), 1244-1258.
| Tipologia: | Articolo su rivista |
| Citazione: | Riccioni, R., Senese, M., Diverio, D., Riti, V., Mariani, G., Boe, A., et al. (2008). Resistance of acute myeloid leukemic cells to the triterpenoid CDDO-Imidazolide is associated with low caspase-8 and FADD levels. LEUKEMIA RESEARCH, 32(8), 1244-1258. |
| IF: | Con Impact Factor ISI |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore MED/15 - Malattie del Sangue |
| Revisione (peer review): | Sì, ma tipo non specificato |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.leukres.2007.12.008 |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | 2008 |
| Titolo: | Resistance of acute myeloid leukemic cells to the triterpenoid CDDO-Imidazolide is associated with low caspase-8 and FADD levels |
| Autori: | |
| Autori: | Riccioni, R; Senese, M; Diverio, D; Riti, V; Mariani, G; Boe, A; Lo Coco, F; Foa, R; Peschle, C; Sporn, M; Testa, U |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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